ENSDARG00000078864


Danio rerio

Features
Gene ID: ENSDARG00000078864
  
Biological name :lats2
  
Synonyms : large tumor suppressor kinase 2 / lats2
  
Possible biological names infered from orthology : Q7TSJ6 / Q9NRM7 / Serine/threonine-protein kinase LATS2
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 21277846
Gene end: 21299336
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000114142
Ensembl peptide - ENSDARP00000098124
Ensembl peptide - ENSDARP00000102394
Ensembl peptide - ENSDARP00000102587
NCBI entrez gene - 567674     See in Manteia.
RefSeq - NM_001123307
RefSeq - NM_001128256
RefSeq Peptide - NP_001116779
RefSeq Peptide - NP_001121728
swissprot - F1QGL3
swissprot - B0S8I4
swissprot - F6NHD1
ZFIN ID - ZDB-GENE-050119-6
Ensembl - ENSDARG00000078864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LATS2ENSG00000150457Homo sapiens
 Lats2ENSMUSG00000114942Mus musculus
 Lats2ENSMUSG00000021959Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lats1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *ENSDARG0000000375144
stk38a / serine/threonine kinase 38a / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001997318
stk38l / serine/threonine kinase 38 like / Q7TSE6* / Q9Y2H1* / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA.*ENSDARG0000004548217
stk38b / serine/threonine kinase 38b / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001851617
cdc42bpaa / CDC42 binding protein kinase alpha (DMPK-like) a / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000010428315
rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*ENSDARG0000005899315
rock2a / rho-associated, coiled-coil containing protein kinase 2a / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000001750015
cdc42bpab / CDC42 binding protein kinase alpha (DMPK-like) b / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000001646415
cdc42bpb / CDC42 binding protein kinase beta (DMPK-like)ENSDARG0000001938314
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000000487713
DMPK / DM1 protein kinase / Q09013*ENSDARG0000007491413
cita / citron rho-interacting serine/threonine kinase aENSDARG0000008985612
si:dkey-65b13.9 / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG000001052497
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG000000964331
citb / citron rho-interacting serine/threonine kinase b / CIT* / O14578* / citron rho-interacting serine/threonine kinase*ENSDARG000000888251


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR009060  UBA-like superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035329 hippo signaling IBA
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0046620 regulation of organ growth IBA
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 cellular_componentGO:0000922 spindle pole IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011312 stk3 / Q7ZUQ3 / serine/threonine kinase 3 (STE20 homolog, yeast) / Q13188* / Q9JI10* / serine/threonine kinase 3* / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA.*  / reaction
 ENSDARG00000076041 wwc1 / WW and C2 domain containing 1 / Q8IX03*  / complex / reaction
 ENSDARG00000068401 yap1 / Q1L8J7 / Yes-associated protein 1 / P46937* / P46938*  / reaction
 ENSDARG00000009169 mob1ba / MOB kinase activator 1Ba / MOB1B* / Q8BPB0* / Q7L9L4* / MOB kinase activator 1B*  / complex / reaction
 ENSDARG00000067719 wwtr1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / reaction






 

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