ENSDARG00000067719


Danio rerio

Features
Gene ID: ENSDARG00000067719
  
Biological name :wwtr1
  
Synonyms : WW domain containing transcription regulator 1 / wwtr1
  
Possible biological names infered from orthology : Q9EPK5 / Q9GZV5
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 38049130
Gene end: 38114599
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000088304
NCBI entrez gene - 568008     See in Manteia.
swissprot - Q307I6
ZFIN ID - ZDB-GENE-051101-1
Ensembl - ENSDARG00000067719
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WWTR1ENSGALG00000010412Gallus gallus
 WWTR1ENSG00000018408Homo sapiens
 Wwtr1ENSMUSG00000027803Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
yap1 / Q1L8J7 / Yes-associated protein 1 / P46937* / P46938*ENSDARG0000006840146


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0003406 retinal pigment epithelium development IGI
 biological_processGO:0034672 anterior/posterior pattern specification involved in pronephros development IMP
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IMP
 biological_processGO:0072148 epithelial cell fate commitment IMP


Pathways (from Reactome)
Pathway description
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle trabecula formation decreased process quality , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer malformed , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium absent , abnormal
retinal pigmented epithelium malformed , abnormal
Show

 ZFA:0001072 thyroid follicle thyroid follicle spatial pattern , abnormal
thyroid follicle decreased amount , abnormal
thyroid follicle decreased diameter , abnormal
Show

 ZFA:0001081 thyroid primordium thyroid primordium increased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism increased amount , abnormal
whole organism decreased amount , abnormal
Show

 ZFA:0001293 posterior kidney posterior kidney cystic , abnormal
Show

 ZFA:0005003 pharyngeal vasculature pharyngeal vasculature morphology , abnormal
Show

 ZFA:0005004 aortic arch aortic arch dysplastic , abnormal
Show

 ZFA:0005060 trabecular layer of ventricle trabecular layer of ventricle malformed , abnormal
trabecular layer of ventricle lacks parts or has fewer parts of type cardiac muscle cell , abnormal
Show

 ZFA:0005062 compact layer of ventricle compact layer of ventricle cortical actin cytoskeleton spatial pattern , abnormal
compact layer of ventricle cortical actin cytoskeleton malformed , abnormal
compact layer of ventricle plasma membrane part of cell junction oblique orientation , abnormal
Show

 ZFA:0005249 vasculature vasculature hemorrhagic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003751 lats1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *  / reaction
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSDARG00000006399 ywhae1 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 / YWHAE* / P62259* / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase act...  / complex / reaction
 ENSDARG00000019442 AMOTL1 / angiomotin like 1 / Q8IY63*  / reaction / complex
 ENSDARG00000061923 A1YB07 / amotl2a / angiomotin like 2a / AMOTL2* / Q8K371* / Q9Y2J4* / angiomotin like 2* / Angiomotin-like protein 2 *  / reaction / complex
 ENSDARG00000078864 lats2 / large tumor suppressor kinase 2 / Q7TSJ6* / Q9NRM7* / Serine/threonine-protein kinase LATS2 *  / reaction
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000078335 amot / angiomotin / Q4VCS5*  / complex / reaction
 ENSDARG00000061948 amotl2b / angiomotin like 2b / AMOTL2* / Q8K371* / Q9Y2J4* / angiomotin like 2* / Angiomotin-like protein 2 *  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr