ENSMUSG00000027803


Mus musculus

Features
Gene ID: ENSMUSG00000027803
  
Biological name :Wwtr1
  
Synonyms : Q9EPK5 / WW domain containing transcription regulator 1 / Wwtr1
  
Possible biological names infered from orthology : Q9GZV5
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: D
Gene start: 57455649
Gene end: 57575910
  
Corresponding Affymetrix probe sets: 10498284 (MoGene1.0st)   1417817_a_at (Mouse Genome 430 2.0 Array)   1417818_at (Mouse Genome 430 2.0 Array)   1437155_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029380
Ensembl peptide - ENSMUSP00000113040
NCBI entrez gene - 97064     See in Manteia.
MGI - MGI:1917649
RefSeq - NM_001168281
RefSeq - NM_133784
RefSeq Peptide - NP_001161753
RefSeq Peptide - NP_598545
swissprot - Q9EPK5
Ensembl - ENSMUSG00000027803
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wwtr1ENSDARG00000067719Danio rerio
 WWTR1ENSGALG00000010412Gallus gallus
 WWTR1ENSG00000018408Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Yap1 / P46938 / yes-associated protein 1 / P46937*ENSMUSG0000005311044


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0017145 stem cell division IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032835 glomerulus development IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048762 mesenchymal cell differentiation IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060390 regulation of SMAD protein signal transduction IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0060993 kidney morphogenesis IMP
 biological_processGO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation IGI
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0000524 reduced renal tubule number "fewer loops of Henle and collecting ducts" [J:40203]
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Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Lats1tm1Noj/Lats1tm1Noj,Lats2tm1.1Dupa/Lats2tm1.1Dupa,Wwtr1tm1.2Eno/Wwtr1tm1.2Eno,Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Apcstm1Smae/Apcstm1Smae
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1tm1.1Eno,Yap1tm1.1Eno/Yap1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

Allelic Composition: Wwtr1tm1.1Eno/Wwtr1tm1.1Eno,Yap1tm1.1Eno/Yap1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002314 abnormal respiratory mechanics "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0002704 tubular nephritis "inflammation of the renal tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1tm1.1Eno,Yap1tm1.1Eno/Yap1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Wwtr1tm1Hku/Wwtr1tm1Hku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Wwtr1tm1Hku/Wwtr1tm1Hku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

Allelic Composition: Wwtr1Gt(CSD245)Byg/Wwtr1Gt(CSD245)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aestm1.1Mmt/Aestm1.1Mmt,Apctm1Mmt/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA * SJL

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

Allelic Composition: Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Genetic Background: involves: 129S/SvEv

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0009051 dilated distal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0010500 myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0010887 pale lung "lung lacking normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0010903 abnormal pulmonary alveolus wall morphology 
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0010922 alveolitis "inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0011045 decreased lung elastance "reduced ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [MGI:anna]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0011066 abnormal renal tubule epithelial cell primary cilium morphology "any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Wwtr1tm1Hku/Wwtr1tm1Hku
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: ArTfm-Jms/Y
Genetic Background: C57BL/6JJms

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S6/SvEvTac-Wwtr1tm1Benj

Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0011308 kidney corticomedullary cysts "development of abnormal membranous sacs in the corticomedullary junction of the kidney" [MGI:anna]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0012236 abnormal cholangiocyte morphology "any structural anomaly of the epithelial cells of the bile duct that have primary cilia extending from their apical membrane into the ductal lumen; cholangiocytes are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts" [PMID:22961800]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Wwtr1tm1Hku/Wwtr1tm1Hku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0013611 abnormal bile duct epithelium morphology "any structural anomaly of the epithelium lining the intrahepatic and extrahepatic bile ducts" [MGI:Anna]
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Allelic Composition: Lats1tm1Noj/Lats1tm1Noj,Lats2tm1.1Dupa/Lats2tm1.1Dupa,Wwtr1tm1.2Eno/Wwtr1tm1.2Eno,Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000021959 Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*  / reaction
 ENSMUSG00000041688 Amot / Q8VHG2 / Angiomotin / Q4VCS5*  / complex / reaction
 ENSMUSG00000030516 Tjp1 / P39447 / tight junction protein 1 / Q07157*  / complex / reaction
 ENSMUSG00000013076 Amotl1 / Q9D4H4 / Angiomotin-like protein 1 / Q8IY63* / angiomotin like 1*  / reaction / complex
 ENSMUSG00000018263 Tbx5 / P70326 / T-box 5 / Q99593*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000030796 Tead2 / P48301 / TEA domain family member 2 / Q15562* / TEA domain transcription factor 2*  / complex / reaction
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / reaction / complex
 ENSMUSG00000032531 Amotl2 / Q8K371 / Angiomotin-like protein 2 / Q9Y2J4* / angiomotin like 2*  / reaction / complex
 ENSMUSG00000002249 Tead3 / P70210 / TEA domain family member 3 / Q99594* / TEA domain transcription factor 3*  / reaction / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000024812 Tjp2 / Q9Z0U1 / Tight junction protein ZO-2 / Q9UDY2* / AL358113.1* / tight junction protein 2*  / complex / reaction
 ENSMUSG00000000708 Kat2b / Q9JHD1 / Histone acetyltransferase KAT2B / Q92831* / lysine acetyltransferase 2B*  / reaction / complex
 ENSMUSG00000040021 Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*  / reaction
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / complex / reaction






 

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