ENSMUSG00000002249


Mus musculus

Features
Gene ID: ENSMUSG00000002249
  
Biological name :Tead3
  
Synonyms : P70210 / Tead3 / TEA domain family member 3
  
Possible biological names infered from orthology : Q99594 / TEA domain transcription factor 3
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 28331671
Gene end: 28350805
  
Corresponding Affymetrix probe sets: 10449419 (MoGene1.0st)   1420593_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110447
Ensembl peptide - ENSMUSP00000115443
Ensembl peptide - ENSMUSP00000118582
Ensembl peptide - ENSMUSP00000152030
NCBI entrez gene - 21678     See in Manteia.
MGI - MGI:109241
RefSeq - NM_001098226
RefSeq - NM_001204156
RefSeq - NM_011566
RefSeq Peptide - NP_001191085
RefSeq Peptide - NP_035696
RefSeq Peptide - NP_001091696
swissprot - P70210
swissprot - F6TTJ9
swissprot - F8VPU0
Ensembl - ENSMUSG00000002249
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tead3aENSDARG00000074321Danio rerio
 tead3bENSDARG00000063649Danio rerio
 TEAD3ENSGALG00000043513Gallus gallus
 TEAD3ENSG00000007866Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tead4 / TEA domain family member 4 / Q15561* / TEA domain transcription factor 4*ENSMUSG0000003035364
Tead1 / TEA domain family member 1 / P28347* / TEA domain transcription factor 1*ENSMUSG0000005532064
Tead2 / P48301 / TEA domain family member 2 / Q15562* / TEA domain transcription factor 2*ENSMUSG0000003079660


Protein motifs (from Interpro)
Interpro ID Name
 IPR000818  TEA/ATTS domain
 IPR016361  Transcriptional enhancer factor, metazoa
 IPR027253  Transcriptional enhancer factor TEF-5 (TEAD3)


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0035329 hippo signaling IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048568 embryonic organ development IBA
 biological_processGO:0055059 asymmetric neuroblast division ISO
 biological_processGO:1902459 positive regulation of stem cell population maintenance IGI
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IGI
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0013022 increased Ly6C high monocyte number "increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / complex / reaction
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / complex / reaction






 

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contact: otassy@igbmc.fr