ENSMUSG00000055320


Mus musculus

Features
Gene ID: ENSMUSG00000055320
  
Biological name :Tead1
  
Synonyms : Tead1 / TEA domain family member 1
  
Possible biological names infered from orthology : P28347 / TEA domain transcription factor 1
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F1
Gene start: 112679318
Gene end: 112906807
  
Corresponding Affymetrix probe sets: 10556442 (MoGene1.0st)   10556456 (MoGene1.0st)   1423434_at (Mouse Genome 430 2.0 Array)   1429556_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130459
Ensembl peptide - ENSMUSP00000129798
Ensembl peptide - ENSMUSP00000130564
Ensembl peptide - ENSMUSP00000133025
Ensembl peptide - ENSMUSP00000131765
Ensembl peptide - ENSMUSP00000131221
Ensembl peptide - ENSMUSP00000060671
Ensembl peptide - ENSMUSP00000081755
Ensembl peptide - ENSMUSP00000102249
Ensembl peptide - ENSMUSP00000127574
Ensembl peptide - ENSMUSP00000128439
NCBI entrez gene - 21676     See in Manteia.
MGI - MGI:101876
RefSeq - XM_011241724
RefSeq - NM_001166584
RefSeq - NM_001166585
RefSeq - NM_009346
RefSeq - XM_006507561
RefSeq - XM_006507562
RefSeq - XM_006507563
RefSeq - XM_006507564
RefSeq - XM_006507565
RefSeq - XM_011241723
RefSeq Peptide - NP_001160057
RefSeq Peptide - NP_033372
RefSeq Peptide - NP_001160056
swissprot - E9QAK6
swissprot - E9Q387
swissprot - E9PZ73
swissprot - F6QH05
swissprot - E9PVS2
swissprot - Q3USK5
swissprot - Q6PAQ8
swissprot - E9PVJ5
swissprot - Q3UFP5
Ensembl - ENSMUSG00000055320
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tead1bENSDARG00000059483Danio rerio
 TEAD1ENSGALG00000005415Gallus gallus
 TEAD1ENSG00000187079Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tead4 / TEA domain family member 4 / Q15561* / TEA domain transcription factor 4*ENSMUSG0000003035372
Tead3 / P70210 / TEA domain family member 3 / Q99594* / TEA domain transcription factor 3*ENSMUSG0000000224968
Tead2 / P48301 / TEA domain family member 2 / Q15562* / TEA domain transcription factor 2*ENSMUSG0000003079663


Protein motifs (from Interpro)
Interpro ID Name
 IPR000818  TEA/ATTS domain
 IPR016361  Transcriptional enhancer factor, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000828 abnormal fourth ventricle morphology "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Tead1tm1b(KOMP)Wtsi/Tead1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tead1tm1b(KOMP)Wtsi/Bay

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

Allelic Composition: Tead1tm1b(KOMP)Wtsi/Tead1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tead1tm1b(KOMP)Wtsi/Bay

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1.1Wtp/Srftm1.1Wtp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008534 enlarged fourth ventricle "increased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [MESH:A08.186.211.276.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

Allelic Composition: Tead1tm1b(KOMP)Wtsi/Tead1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tead1tm1b(KOMP)Wtsi/Bay

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0013217 abnormal posterior definitive endoderm morphology "any structural anomaly of the posterior region of the definitive endoderm which evolves into the midgut and hindgut, which will eventually differentiate into the large and small intestine" [PMID:0080555950]
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Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Tead1tm1b(KOMP)Wtsi/Tead1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tead1tm1b(KOMP)Wtsi/Bay

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

Allelic Composition: Tead1tm1b(KOMP)Wtsi/Tead1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tead1tm1b(KOMP)Wtsi/Bay

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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