ENSMUSG00000030353


Mus musculus

Features
Gene ID: ENSMUSG00000030353
  
Biological name :Tead4
  
Synonyms : Tead4 / TEA domain family member 4
  
Possible biological names infered from orthology : Q15561 / TEA domain transcription factor 4
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 128224288
Gene end: 128300823
  
Corresponding Affymetrix probe sets: 10548146 (MoGene1.0st)   1426337_a_at (Mouse Genome 430 2.0 Array)   1460683_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118083
Ensembl peptide - ENSMUSP00000120941
Ensembl peptide - ENSMUSP00000118606
Ensembl peptide - ENSMUSP00000006311
Ensembl peptide - ENSMUSP00000107784
NCBI entrez gene - 21679     See in Manteia.
MGI - MGI:106907
RefSeq - NM_011567
RefSeq - NM_001080979
RefSeq Peptide - NP_035697
RefSeq Peptide - NP_001074448
swissprot - F6UKF4
swissprot - A0A0R4IZY5
swissprot - A0A0R4J1U4
swissprot - F6ULG6
Ensembl - ENSMUSG00000030353
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TEAD4ENSGALG00000014342Gallus gallus
 TEAD4ENSG00000197905Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tead1 / TEA domain family member 1 / P28347* / TEA domain transcription factor 1*ENSMUSG0000005532073
Tead3 / P70210 / TEA domain family member 3 / Q99594* / TEA domain transcription factor 3*ENSMUSG0000000224969
Tead2 / P48301 / TEA domain family member 2 / Q15562* / TEA domain transcription factor 2*ENSMUSG0000003079662


Protein motifs (from Interpro)
Interpro ID Name
 IPR000818  TEA/ATTS domain
 IPR016361  Transcriptional enhancer factor, metazoa
 IPR027255  Transcriptional enhancer factor TEF-3 (TEAD4)


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0035329 hippo signaling IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001714 absent trophoblast cells "missing cells of the extraembryonic cell layer that contribute to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp14sabe/Mmp14sabe
Genetic Background: B6(129P2)-Mmp14sabe/GrsrJ

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0012058 abnormal morula morphology "any structural anomaly of the globular solid mass of blastomeres formed by cleavage of a zygote that typically precedes the blastula, typically after the zygote has divided into 32 cells" [MGI:anna]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0012102 absent trophectoderm "absence of the outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo s means of nutrition" [MGI:anna]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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