ENSMUSG00000030796


Mus musculus

Features
Gene ID: ENSMUSG00000030796
  
Biological name :Tead2
  
Synonyms : P48301 / Tead2 / TEA domain family member 2
  
Possible biological names infered from orthology : Q15562 / TEA domain transcription factor 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45215753
Gene end: 45233644
  
Corresponding Affymetrix probe sets: 10552874 (MoGene1.0st)   1448519_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103431
Ensembl peptide - ENSMUSP00000148183
Ensembl peptide - ENSMUSP00000148005
Ensembl peptide - ENSMUSP00000147746
Ensembl peptide - ENSMUSP00000147727
Ensembl peptide - ENSMUSP00000147321
Ensembl peptide - ENSMUSP00000147288
Ensembl peptide - ENSMUSP00000033060
Ensembl peptide - ENSMUSP00000103430
NCBI entrez gene - 21677     See in Manteia.
MGI - MGI:104904
RefSeq - XM_011250842
RefSeq - NM_001285498
RefSeq - NM_001285500
RefSeq - NM_011565
RefSeq - XM_006540777
RefSeq Peptide - NP_035695
RefSeq Peptide - NP_001272427
RefSeq Peptide - NP_001272429
swissprot - A0A1B0GT36
swissprot - P48301
swissprot - A0A1B0GS07
swissprot - A0A1B0GRZ4
swissprot - A0A1B0GR00
swissprot - A0A1B0GSN2
swissprot - A0A1B0GQX1
swissprot - Q3UPV9
swissprot - Q80UL2
Ensembl - ENSMUSG00000030796
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TEAD2ENSG00000074219Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tead3 / P70210 / TEA domain family member 3 / Q99594* / TEA domain transcription factor 3*ENSMUSG0000000224963
Tead1 / TEA domain family member 1 / P28347* / TEA domain transcription factor 1*ENSMUSG0000005532062
Tead4 / TEA domain family member 4 / Q15561* / TEA domain transcription factor 4*ENSMUSG0000003035359


Protein motifs (from Interpro)
Interpro ID Name
 IPR000818  TEA/ATTS domain
 IPR016361  Transcriptional enhancer factor, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IGI
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030903 notochord development IGI
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048339 paraxial mesoderm development IGI
 biological_processGO:0048368 lateral mesoderm development IGI
 biological_processGO:0060548 negative regulation of cell death IGI
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0071300 cellular response to retinoic acid IDA
 biological_processGO:2000736 regulation of stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0071149 TEAD-2-YAP complex IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001134 transcription factor activity, transcription factor recruiting IEA
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bicc1b2b222Clo/Bicc1b2b222Clo
Genetic Background: C57BL/6J-Bicc1b2b222Clo

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Tead2tm1.1Mldp/Tead2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0013217 abnormal posterior definitive endoderm morphology "any structural anomaly of the posterior region of the definitive endoderm which evolves into the midgut and hindgut, which will eventually differentiate into the large and small intestine" [PMID:0080555950]
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Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / complex / reaction
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / reaction / complex






 

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