ENSG00000074219


Homo sapiens

Features
Gene ID: ENSG00000074219
  
Biological name :TEAD2
  
Synonyms : Q15562 / TEAD2 / TEA domain transcription factor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 49340595
Gene end: 49362457
  
Corresponding Affymetrix probe sets: 226408_at (Human Genome U133 Plus 2.0 Array)   238322_s_at (Human Genome U133 Plus 2.0 Array)   238323_at (Human Genome U133 Plus 2.0 Array)   243766_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472109
Ensembl peptide - ENSP00000471743
Ensembl peptide - ENSP00000472397
Ensembl peptide - ENSP00000310701
Ensembl peptide - ENSP00000366419
Ensembl peptide - ENSP00000437928
Ensembl peptide - ENSP00000469640
Ensembl peptide - ENSP00000469672
NCBI entrez gene - 8463     See in Manteia.
OMIM - 601729
RefSeq - XM_011527404
RefSeq - NM_003598
RefSeq - XM_005259334
RefSeq - XM_006723424
RefSeq - XM_006723428
RefSeq - XM_011527398
RefSeq - XM_011527399
RefSeq - XM_011527400
RefSeq - XM_011527401
RefSeq - XM_011527402
RefSeq - XM_011527403
RefSeq - NM_001256658
RefSeq - NM_001256659
RefSeq - NM_001256660
RefSeq - NM_001256661
RefSeq - NM_001256662
RefSeq Peptide - NP_001243588
RefSeq Peptide - NP_001243590
RefSeq Peptide - NP_001243591
RefSeq Peptide - NP_003589
RefSeq Peptide - NP_001243587
RefSeq Peptide - NP_001243589
swissprot - M0R290
swissprot - M0R1A5
swissprot - Q15562
swissprot - A0A024QZE2
Ensembl - ENSG00000074219
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Tead2ENSMUSG00000030796Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TEAD1 / P28347 / TEA domain transcription factor 1ENSG0000018707963
TEAD3 / Q99594 / TEA domain transcription factor 3ENSG0000000786661
TEAD4 / Q15561 / TEA domain transcription factor 4ENSG0000019790560


Protein motifs (from Interpro)
Interpro ID Name
 IPR000818  TEA/ATTS domain
 IPR016361  Transcriptional enhancer factor, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0003143 embryonic heart tube morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0030903 notochord development IEA
 biological_processGO:0035329 hippo signaling IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048339 paraxial mesoderm development IEA
 biological_processGO:0048368 lateral mesoderm development IEA
 biological_processGO:0048568 embryonic organ development IBA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0065003 protein-containing complex assembly IMP
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:2000736 regulation of stem cell differentiation IEA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0071149 TEAD-2-YAP complex IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001134 transcription factor activity, transcription factor recruiting IMP
 molecular_functionGO:0001223 transcription coactivator binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0097718 disordered domain specific binding IMP


Pathways (from Reactome)
Pathway description
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000018408 WWTR1 / Q9GZV5 / WW domain containing transcription regulator 1  / reaction / complex
 ENSG00000137693 YAP1 / P46937 / Yes associated protein 1  / complex / reaction






 

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