ENSG00000187079


Homo sapiens

Features
Gene ID: ENSG00000187079
  
Biological name :TEAD1
  
Synonyms : P28347 / TEAD1 / TEA domain transcription factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.3
Gene start: 12674591
Gene end: 12944483
  
Corresponding Affymetrix probe sets: 1553322_s_at (Human Genome U133 Plus 2.0 Array)   214600_at (Human Genome U133 Plus 2.0 Array)   224955_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000334754
Ensembl peptide - ENSP00000435393
Ensembl peptide - ENSP00000491500
Ensembl peptide - ENSP00000435977
Ensembl peptide - ENSP00000432587
Ensembl peptide - ENSP00000435233
NCBI entrez gene - 7003     See in Manteia.
OMIM - 189967
RefSeq - NM_021961
RefSeq Peptide - NP_068780
swissprot - H0YE88
swissprot - E9PKB7
swissprot - P28347
swissprot - H0YEJ9
swissprot - H0YCZ6
Ensembl - ENSG00000187079
  
Related genetic diseases (OMIM): 108985 - Sveinsson chorioretinal atrophy, 108985

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tead1bENSDARG00000059483Danio rerio
 TEAD1ENSGALG00000005415Gallus gallus
 Tead1ENSMUSG00000055320Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TEAD4 / Q15561 / TEA domain transcription factor 4ENSG0000019790575
TEAD3 / Q99594 / TEA domain transcription factor 3ENSG0000000786671
TEAD2 / Q15562 / TEA domain transcription factor 2ENSG0000007421966


Protein motifs (from Interpro)
Interpro ID Name
 IPR000818  TEA/ATTS domain
 IPR016361  Transcriptional enhancer factor, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0035329 hippo signaling IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048568 embryonic organ development IBA
 biological_processGO:0065003 protein-containing complex assembly IMP
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0071148 TEAD-1-YAP complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001134 transcription factor activity, transcription factor recruiting IMP
 molecular_functionGO:0001223 transcription coactivator binding IPI
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000483 Astigmatism 
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 HP:0000545 Myopia 
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 HP:0003677 Slow progression 
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 HP:0007950 Peripapillary chorioretinal atrophy 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000020633 RUNX3 / Q13761 / runt related transcription factor 3  / complex / reaction
 ENSG00000018408 WWTR1 / Q9GZV5 / WW domain containing transcription regulator 1  / complex / reaction
 ENSG00000137693 YAP1 / P46937 / Yes associated protein 1  / complex / reaction






 

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