ENSG00000020633


Homo sapiens

Features
Gene ID: ENSG00000020633
  
Biological name :RUNX3
  
Synonyms : Q13761 / runt related transcription factor 3 / RUNX3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.11
Gene start: 24899511
Gene end: 24965121
  
Corresponding Affymetrix probe sets: 204197_s_at (Human Genome U133 Plus 2.0 Array)   204198_s_at (Human Genome U133 Plus 2.0 Array)   234928_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000382800
Ensembl peptide - ENSP00000308051
Ensembl peptide - ENSP00000343477
NCBI entrez gene - 864     See in Manteia.
OMIM - 600210
RefSeq - XM_011542351
RefSeq - NM_001031680
RefSeq - NM_001320672
RefSeq - NM_004350
RefSeq - XM_005246024
RefSeq Peptide - NP_001307601
RefSeq Peptide - NP_004341
RefSeq Peptide - NP_001026850
swissprot - Q13761
swissprot - A0A024RAH4
Ensembl - ENSG00000020633
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 runx3ENSDARG00000052826Danio rerio
 RUNX3ENSGALG00000043372Gallus gallus
 Runx3ENSMUSG00000070691Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RUNX2 / Q13950 / runt related transcription factor 2ENSG0000012481361
RUNX1 / Q01196 / runt related transcription factor 1ENSG0000015921660


Protein motifs (from Interpro)
Interpro ID Name
 IPR000040  Acute myeloid leukemia 1 protein (AML1)/Runt
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013524  Runt domain
 IPR013711  Runx, C-terminal domain
 IPR016554  Runt-related transcription factor RUNX
 IPR027384  Runx, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001503 ossification IBA
 biological_processGO:0002062 chondrocyte differentiation IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0030097 hemopoiesis IBA
 biological_processGO:0045595 regulation of cell differentiation IBA
 biological_processGO:0045786 negative regulation of cell cycle ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048935 peripheral nervous system neuron development TAS
 biological_processGO:0050680 negative regulation of epithelial cell proliferation ISS
 biological_processGO:0071559 response to transforming growth factor beta IDA
 cellular_componentGO:0000790 nuclear chromatin ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding NAS


Pathways (from Reactome)
Pathway description
Binding of TCF/LEF:CTNNB1 to target gene promoters
RUNX3 regulates CDKN1A transcription
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 Regulates Immune Response and Cell Migration
RUNX3 regulates WNT signaling
RUNX3 regulates YAP1-mediated transcription
RUNX3 regulates RUNX1-mediated transcription
RUNX3 regulates p14-ARF
RUNX3 regulates BCL2L11 (BIM) transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / complex / reaction
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / reaction / complex
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / reaction / complex
 ENSG00000068024 HDAC4 / P56524 / histone deacetylase 4  / reaction / complex
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / reaction / complex
 ENSG00000187079 TEAD1 / P28347 / TEA domain transcription factor 1  / reaction / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction / complex
 ENSG00000118689 FOXO3 / O43524 / forkhead box O3  / complex / reaction
 ENSG00000137693 YAP1 / P46937 / Yes associated protein 1  / complex / reaction
 ENSG00000197905 TEAD4 / Q15561 / TEA domain transcription factor 4  / reaction / complex
 ENSG00000204256 BRD2 / P25440 / bromodomain containing 2  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000140836 ZFHX3 / Q15911 / zinc finger homeobox 3  / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction






 

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