ENSG00000118689


Homo sapiens

Features
Gene ID: ENSG00000118689
  
Biological name :FOXO3
  
Synonyms : forkhead box O3 / FOXO3 / O43524
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q21
Gene start: 108559835
Gene end: 108684774
  
Corresponding Affymetrix probe sets: 204131_s_at (Human Genome U133 Plus 2.0 Array)   204132_s_at (Human Genome U133 Plus 2.0 Array)   210655_s_at (Human Genome U133 Plus 2.0 Array)   217399_s_at (Human Genome U133 Plus 2.0 Array)   224889_at (Human Genome U133 Plus 2.0 Array)   224891_at (Human Genome U133 Plus 2.0 Array)   231548_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339527
Ensembl peptide - ENSP00000385824
Ensembl peptide - ENSP00000446316
NCBI entrez gene - 2309     See in Manteia.
OMIM - 602681
RefSeq - XM_017010586
RefSeq - NM_001455
RefSeq - NM_201559
RefSeq - XM_005266868
RefSeq - XM_011535628
RefSeq - XM_011535629
RefSeq Peptide - NP_963853
RefSeq Peptide - NP_001446
swissprot - O43524
Ensembl - ENSG00000118689
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxo3aENSDARG00000023058Danio rerio
 foxo3bENSDARG00000042904Danio rerio
 FOXO3ENSGALG00000015297Gallus gallus
 Foxo3ENSMUSG00000048756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXO1 / Q12778 / forkhead box O1ENSG0000015090743
FOXO6 / A8MYZ6 / forkhead box O6ENSG0000020406033
FOXO4 / P98177 / forkhead box O4ENSG0000018448133
FOXM1 / Q08050 / forkhead box M1ENSG0000011120618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR032068  FOXO protein, KIX-binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0001544 initiation of primordial ovarian follicle growth IEA
 biological_processGO:0001547 antral ovarian follicle growth IEA
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006390 mitochondrial transcription IMP
 biological_processGO:0006417 regulation of translation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0034599 cellular response to oxidative stress ISS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043491 protein kinase B signaling TAS
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IDA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071386 cellular response to corticosterone stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death IEA
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990785 response to water-immersion restraint stress IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0001221 transcription cofactor binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031490 chromatin DNA binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
AKT phosphorylates targets in the nucleus
Constitutive Signaling by AKT1 E17K in Cancer
MAPK6/MAPK4 signaling
Interleukin-4 and Interleukin-13 signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
RUNX3 regulates BCL2L11 (BIM) transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000020633 RUNX3 / Q13761 / runt related transcription factor 3  / reaction / complex
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / complex / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / reaction






 

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