ENSG00000184481


Homo sapiens

Features
Gene ID: ENSG00000184481
  
Biological name :FOXO4
  
Synonyms : forkhead box O4 / FOXO4 / P98177
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q13.1
Gene start: 71096197
Gene end: 71103535
  
Corresponding Affymetrix probe sets: 205451_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000342209
Ensembl peptide - ENSP00000363377
NCBI entrez gene - 4303     See in Manteia.
OMIM - 300033
RefSeq - XM_011530957
RefSeq - NM_001170931
RefSeq - NM_005938
RefSeq Peptide - NP_005929
RefSeq Peptide - NP_001164402
swissprot - P98177
Ensembl - ENSG00000184481
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxo4ENSDARG00000055792Danio rerio
 FOXO4ENSGALG00000005658Gallus gallus
 Foxo4ENSMUSG00000042903Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXO1 / Q12778 / forkhead box O1ENSG0000015090747
FOXO3 / O43524 / forkhead box O3ENSG0000011868944
FOXO6 / A8MYZ6 / forkhead box O6ENSG0000020406035
FOXM1 / Q08050 / forkhead box M1ENSG0000011120619


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0043491 protein kinase B signaling TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0051151 negative regulation of smooth muscle cell differentiation IDA
 biological_processGO:0070317 negative regulation of G0 to G1 transition IDA
 biological_processGO:0071158 positive regulation of cell cycle arrest IDA
 biological_processGO:1990785 response to water-immersion restraint stress IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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