ENSG00000150907


Homo sapiens

Features
Gene ID: ENSG00000150907
  
Biological name :FOXO1
  
Synonyms : forkhead box O1 / FOXO1 / Q12778
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q14.11
Gene start: 40469953
Gene end: 40666597
  
Corresponding Affymetrix probe sets: 202723_s_at (Human Genome U133 Plus 2.0 Array)   202724_s_at (Human Genome U133 Plus 2.0 Array)   228484_s_at (Human Genome U133 Plus 2.0 Array)   233432_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368880
NCBI entrez gene - 2308     See in Manteia.
OMIM - 136533
RefSeq - NM_002015
RefSeq Peptide - NP_002006
swissprot - Q12778
Ensembl - ENSG00000150907
  
Related genetic diseases (OMIM): 268220 - Rhabdomyosarcoma, alveolar, 268220

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A3RK74ENSDARG00000099555Danio rerio
 A3RK75ENSDARG00000061549Danio rerio
 FOXO1ENSGALG00000017034Gallus gallus
 Foxo1ENSMUSG00000044167Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXO3 / O43524 / forkhead box O3ENSG0000011868944
FOXO4 / P98177 / forkhead box O4ENSG0000018448136
FOXO6 / A8MYZ6 / forkhead box O6ENSG0000020406029
FOXM1 / Q08050 / forkhead box M1ENSG0000011120617


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR032068  FOXO protein, KIX-binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001659 temperature homeostasis ISS
 biological_processGO:0001678 cellular glucose homeostasis ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006473 protein acetylation ISS
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0009267 cellular response to starvation ISS
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0010508 positive regulation of autophagy IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade IDA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043491 protein kinase B signaling TAS
 biological_processGO:0045444 fat cell differentiation ISS
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045722 positive regulation of gluconeogenesis IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0070166 enamel mineralization IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070417 cellular response to cold ISS
 biological_processGO:0071455 cellular response to hyperoxia IDA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:1902617 response to fluoride IEA
 biological_processGO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus
Regulation of gene expression in beta cells
AKT-mediated inactivation of FOXO1A
Constitutive Signaling by AKT1 E17K in Cancer
MAPK6/MAPK4 signaling
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0006779 Alveolar rhabdomyosarcoma 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / reaction






 

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