ENSGALG00000017034


Gallus gallus

Features
Gene ID: ENSGALG00000017034
  
Biological name :FOXO1
  
Synonyms : forkhead box protein O1 / FOXO1
  
Possible biological names infered from orthology : forkhead box O1 / Q12778 / Q9R1E0
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 170581377
Gene end: 170644995
  
Corresponding Affymetrix probe sets: Gga.3406.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000056572
Ensembl peptide - ENSGALP00000027470
NCBI entrez gene - 374231     See in Manteia.
RefSeq - NM_204328
RefSeq Peptide - NP_989659
swissprot - F1P592
swissprot - A0A1D5PUG9
Ensembl - ENSGALG00000017034
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A3RK74ENSDARG00000099555Danio rerio
 A3RK75ENSDARG00000061549Danio rerio
 FOXO1ENSG00000150907Homo sapiens
 Foxo1ENSMUSG00000044167Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXO3 / forkhead box O3 / O43524* / Q9WVH4* / Forkhead box protein O3 *ENSGALG0000001529737
FOXO4 / forkhead box O4 / P98177* / Q9WVH3* / Forkhead box protein O4 *ENSGALG0000000565833
FOXO6 / forkhead box O6 / A8MYZ6* / Q70KY4* / Forkhead box protein O6 *ENSGALG0000002615325
FOXM1 / forkhead box protein M1 / Q08050* / forkhead box M1*ENSGALG0000001342013
FOXM1* / Q08050* / forkhead box M1*ENSGALG000000407344


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR032068  FOXO protein, KIX-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045722 positive regulation of gluconeogenesis IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071455 cellular response to hyperoxia IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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