ENSGALG00000015297


Gallus gallus

Features
Gene ID: ENSGALG00000015297
  
Biological name :FOXO3
  
Synonyms : forkhead box O3 / FOXO3
  
Possible biological names infered from orthology : Forkhead box protein O3 / O43524 / Q9WVH4
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 67450300
Gene end: 67533242
  
Corresponding Affymetrix probe sets: Gga.15325.1.S1_at (Chicken Array)   Gga.15797.1.S1_at (Chicken Array)   Gga.19700.1.S1_at (Chicken Array)   GgaAffx.24644.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000024641
NCBI entrez gene - 421769     See in Manteia.
RefSeq - XM_001234495
swissprot - F1NNE8
Ensembl - ENSGALG00000015297
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxo3aENSDARG00000023058Danio rerio
 foxo3bENSDARG00000042904Danio rerio
 FOXO3ENSG00000118689Homo sapiens
 Foxo3ENSMUSG00000048756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXO1 / forkhead box protein O1 / Q12778* / Q9R1E0* / forkhead box O1*ENSGALG0000001703442
FOXO4 / forkhead box O4 / P98177* / Q9WVH3* / Forkhead box protein O4 *ENSGALG0000000565835
FOXO6 / forkhead box O6 / A8MYZ6* / Q70KY4* / Forkhead box protein O6 *ENSGALG0000002615333
FOXM1 / forkhead box protein M1 / Q08050* / forkhead box M1*ENSGALG0000001342015
FOXM1* / Q08050* / forkhead box M1*ENSGALG000000407344


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR032068  FOXO protein, KIX-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0001544 initiation of primordial ovarian follicle growth IEA
 biological_processGO:0001547 antral ovarian follicle growth IEA
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006390 mitochondrial transcription IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
AKT phosphorylates targets in the nucleus
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004743 MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41* / O54992* / Gm42878* / MAP kinase-activated protein kinase 5 *  / reaction
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction






 

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