ENSMUSG00000048756


Mus musculus

Features
Gene ID: ENSMUSG00000048756
  
Biological name :Foxo3
  
Synonyms : Forkhead box protein O3 / Foxo3 / Q9WVH4
  
Possible biological names infered from orthology : forkhead box O3 / O43524
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B2
Gene start: 42181841
Gene end: 42276755
  
Corresponding Affymetrix probe sets: 10368886 (MoGene1.0st)   10368888 (MoGene1.0st)   1434831_a_at (Mouse Genome 430 2.0 Array)   1434832_at (Mouse Genome 430 2.0 Array)   1444226_at (Mouse Genome 430 2.0 Array)   1450236_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101141
Ensembl peptide - ENSMUSP00000050683
Ensembl peptide - ENSMUSP00000101140
Ensembl peptide - ENSMUSP00000135355
Ensembl peptide - ENSMUSP00000135380
NCBI entrez gene - 56484     See in Manteia.
MGI - MGI:1890081
RefSeq - XM_006512806
RefSeq - NM_019740
RefSeq Peptide - NP_062714
swissprot - H3BKE2
swissprot - Q9WVH4
swissprot - H9KUZ0
Ensembl - ENSMUSG00000048756
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxo3aENSDARG00000023058Danio rerio
 foxo3bENSDARG00000042904Danio rerio
 FOXO3ENSGALG00000015297Gallus gallus
 FOXO3ENSG00000118689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxo1 / Q9R1E0 / Forkhead box protein O1 / Q12778* / forkhead box O1*ENSMUSG0000004416743
Foxo6 / Q70KY4 / Forkhead box protein O6 / A8MYZ6* / forkhead box O6*ENSMUSG0000005213536
Foxo4 / Q9WVH3 / Forkhead box protein O4 / P98177* / forkhead box O4*ENSMUSG0000004290332
Foxm1 / forkhead box M1 / Q08050*ENSMUSG0000000151718


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR032068  FOXO protein, KIX-binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001542 ovulation from ovarian follicle IMP
 biological_processGO:0001544 initiation of primordial ovarian follicle growth IMP
 biological_processGO:0001547 antral ovarian follicle growth IMP
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006390 mitochondrial transcription IMP
 biological_processGO:0006417 regulation of translation ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IDA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISS
 biological_processGO:0034599 cellular response to oxidative stress IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISO
 biological_processGO:0045648 positive regulation of erythrocyte differentiation ISO
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048854 brain morphogenesis IGI
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071386 cellular response to corticosterone stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0097150 neuronal stem cell population maintenance IGI
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IGI
 biological_processGO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death IEA
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990785 response to water-immersion restraint stress IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IGI
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001221 transcription cofactor binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
AKT phosphorylates targets in the nucleus
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/J

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccna1tm1Coll/Ccna1+
Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * MF1)

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0001749 suppressed circulating follicle stimulating hormone level "repression of secretion into the blood of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:45065, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Oca2p-12DTR/Oca2p
Genetic Background: Not Specified

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Creb1tm3Gsc/Creb1+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Foxo1tm1.1Rdp/Foxo1tm1.1Rdp
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Foxo3tm1.1Rdp/Foxo3+,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Foxo1tm1.1Rdp/Foxo1tm1.1Rdp
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Foxo3tm1.1Rdp/Foxo3+,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

 MP:0002047 hepatic hemangioma "neoplastic- like masses in the liver; often undergoes spontaneous regression" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Foxo1tm1.1Rdp/Foxo1tm1.1Rdp
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col4a3tm1Dec/Col4a3tm1Dec
Genetic Background: 129X1/SvJ-Col4a3tm1Dec

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Oca2p-12DTR/Oca2p
Genetic Background: Not Specified

Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Foxo3tm1Nmt/Foxo3tm1Nmt
Genetic Background: involves: C57BL/6

 MP:0002681 increased number of corpora lutea "greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccna1tm1Coll/Ccna1+
Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * MF1)

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo3tm1Nmt/Foxo3tm1Nmt
Genetic Background: involves: C57BL/6

Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0003505 prolactinoma "a pituitary adenoma characterized by secretion of prolactin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003507 abnormal ovary physiology "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fabp3Gt(XE705)Byg/Fabp3Gt(XE705)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1Nmt/Foxo3tm1Nmt
Genetic Background: involves: C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1Nmt/Foxo3tm1Nmt
Genetic Background: involves: C57BL/6

 MP:0004832 enlarged ovary "increased size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0005068 abnormal NK cell morphology/development "anomalous structure, differentiation, or number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo3tm1Nmt/Foxo3tm1Nmt
Genetic Background: involves: C57BL/6

Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Foxo3tm1.1Rdp/Foxo3tm1.1Rdp,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo3tm1.1Rdp/Foxo3+,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Foxo3Gt(VICTR20)1Kca/Foxo3Gt(VICTR20)1Kca
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009093 oocyte degeneration "a retrogressive impairment of function or destruction of the female germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3Gt(VICTR20)1Kca/Foxo3Gt(VICTR20)1Kca
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0009442 ovarian teratoma "a usually benign tumor found in the ovary that is the result of an anomaly of oogenesis and typically contains a diversity of tissues often representing all organ systems e.g. hair, teeth, bone, thyroid, nerve tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1.1Rdp/Foxo3tm1.1Rdp,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1Nmt/Foxo3tm1Nmt
Genetic Background: involves: C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0010306 increased hamartoma incidence "greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0011121 decreased primordial ovarian follicle number "fewer than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith]
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Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0011125 decreased primary ovarian follicle number "fewer than normal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:csmith]
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Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0011128 increased secondary ovarian follicle number "greater than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith]
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Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0012437 increased Harderian gland tumor incidence "greater than the expected number of neoplams in the Harderian gland, usually in the form of a distinct mass, in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Foxo3tm1.1Rdp/Foxo3tm1.1Rdp,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo3tm1.1Rdp/Foxo3+,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

 MP:0012736 abnormal polar body morphology "any structural anomaly of one of the small cells that are produced during the development of an oocyte and ultimately degenerate; a polar body contains one of the nuclei derived from the first or second meiotic division but little or no cytoplasm" [MGI:anna]
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Allelic Composition: Foxo3mommeR1/Foxo3mommeR1,Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic Background: FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction / complex
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction






 

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