| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Foxm1tm1Cle/Foxm1tm1Cle
Genetic Background: Not Specified
|
| MP:0000279 | ventricular hypoplasia | "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
|
| MP:0000484 | abnormal pulmonary artery morphology | "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator] |
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,Tg(Tagln-cre)1Jomm/0
Genetic Background: involves: CD-1
Allelic Composition: Foxm1tm1Cle/Foxm1tm1Cle
Genetic Background: Not Specified
|
| MP:0001176 | abnormal lung development | "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0001177 | atelectasis | "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: B6.129X1-Foxm1tm1.1Rhc
|
| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
|
| MP:0001953 | respiratory failure | "cessation of or failure to commence breathing" [MGI:cls, J:60159] |
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Allelic Composition: Foxm1tm1Cle/Foxm1tm1Cle
Genetic Background: Not Specified
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0002048 | lung adenoma | "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631] |
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: B6.129X1-Foxm1tm1.1Rhc
|
| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0002188 | small heart | "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044] |
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
|
| MP:0002190 | disorganized myocardium | "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044] |
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Allelic Composition: Foxm1tm1Cle/Foxm1tm1Cle
Genetic Background: Not Specified
|
| MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
|
| MP:0002273 | abnormal alveolar epithelial cell morphology | "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0002275 | abnormal type II pneumocyte morphology | "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Foxm1tm1Cle/Foxm1tm1Cle
Genetic Background: Not Specified
|
| MP:0002658 | abnormal liver regeneration | "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
|
| MP:0002844 | aortic hypertrophy | "increase in the bulk size of the aorta" [RGD:Rat Genome Database submission] |
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0002975 | vascular smooth muscle hypertrophy | "increase in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission] |
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ
|
| MP:0003331 | hepatocellular carcinoma | "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,Tg(Tagln-cre)1Jomm/0
Genetic Background: involves: CD-1
|
| MP:0003336 | pancreatic cysts | "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0003339 | decreased number of pancreatic beta cells | "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0003564 | abnormal insulin secretion | "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0003658 | abnormal capillaries | "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775] |
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0004007 | abnormal lung vasculature | "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
|
| MP:0004181 | abnormal carotid artery morphology | "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
|
| MP:0004391 | abnormal respiratory conducting tube | "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,Tg(Tagln-cre)1Jomm/0
Genetic Background: involves: CD-1
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
|
| MP:0004502 | decreased incidence of chemically-induced tumors | "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
|
| MP:0004564 | enlarged myocardial fiber | "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: B6.129X1-Foxm1tm1.1Rhc
|
| MP:0004567 | decreased myocardial fiber number | "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: B6.129X1-Foxm1tm1.1Rhc
|
| MP:0005215 | abnormal islet of Langerhans morphology | "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0005217 | abnormal pancreatic beta cell morphology | "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
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| MP:0005220 | abnormal exocrine pancreas morphology | "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0008788 | abnormal fetal cardiomyocyte morphology | "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040] |
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: B6.129X1-Foxm1tm1.1Rhc
|
| MP:0008989 | abnormal liver sinusoid morphology | "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ
|
| MP:0009109 | decreased pancreas weight | "reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0009114 | decreased pancreatic beta cell mass | "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0009148 | pancreas necrosis | "pathological cell death in the pancreas, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0009172 | small pancreatic islets | "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
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| MP:0009176 | increased pancreatic alpha cell number | "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
|
| MP:0009497 | abnormal intrahepatic bile duct morphology | "any structural anomaly of the passages within the liver for the conveyance of bile" [MESH:A03.159.183.158] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ
|
| MP:0010018 | lung vascular congestion | "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0010266 | decreased liver tumor incidence | "less than the expected number of neoplams in the liver, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
|
| MP:0010439 | abnormal hepatic vein morphology | "any structural anomaly of the veins that drain blood from the liver and terminate in three large openings to the inferior vena cava below the diaphragm and into smaller openings in more inferior positions" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ
|
| MP:0010499 | abnormal ventricle myocardium morphology | "any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: B6.129X1-Foxm1tm1.1Rhc
|
| MP:0010580 | decreased heart left ventricle size | "less than average size of the left ventricle compared to the average for a particular population" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: B6.129X1-Foxm1tm1.1Rhc
|
| MP:0010816 | decreased type I pneumocyte number | "reduced number of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0010825 | abnormal lung saccule morphology | "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0010827 | small lung saccule | "reduced size of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0010889 | small alveolar lamellar bodies | "decreased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0010993 | decreased surfactant secretion | "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0011018 | pulmonary hyaline membrane formation | "abnormal presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles; hyaline membranes block gas exchange and are usually found at autopsy in individuals that have died of respiratory distress syndrome in the neonatal stages" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ
|
| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
|
| MP:0011112 | partial lethality during fetal growth through weaning | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
|
| MP:0011143 | thick lung-associated mesenchyme | "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6
|
| MP:0011148 | decreased mesenchymal cell proliferation involved in lung development | "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna] |
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
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| MP:0011648 | thick heart valve cusps | "an increase in the heart cusp wall thickness" [MGI:csmith] |
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: B6.129X1-Foxm1tm1.1Rhc
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| MP:0011820 | decreased pancreatic beta cell proliferation | "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169] |
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Allelic Composition: Edardl-J/Edardl-3J
Genetic Background: Not Specified
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| MP:0012240 | abnormal hepatoblast morphology | "any structural anomaly of the bi-potent cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes" [MGI:anna] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ
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| MP:0012243 | decreased hepatoblast number | "reduced number of the bi-potent cells that retain the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes" [MGI:anna] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ
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| MP:0012246 | abnormal hepatic cord morphology | "any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [MGI:anna] |
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Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ
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