ENSMUSG00000044167


Mus musculus

Features
Gene ID: ENSMUSG00000044167
  
Biological name :Foxo1
  
Synonyms : Forkhead box protein O1 / Foxo1 / Q9R1E0
  
Possible biological names infered from orthology : forkhead box O1 / Q12778
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: C
Gene start: 52268336
Gene end: 52353221
  
Corresponding Affymetrix probe sets: 10491962 (MoGene1.0st)   1416981_at (Mouse Genome 430 2.0 Array)   1416982_at (Mouse Genome 430 2.0 Array)   1416983_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055308
NCBI entrez gene - 56458     See in Manteia.
MGI - MGI:1890077
RefSeq - NM_019739
RefSeq Peptide - NP_062713
swissprot - Q9R1E0
Ensembl - ENSMUSG00000044167
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A3RK74ENSDARG00000099555Danio rerio
 A3RK75ENSDARG00000061549Danio rerio
 FOXO1ENSGALG00000017034Gallus gallus
 FOXO1ENSG00000150907Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxo3 / Q9WVH4 / Forkhead box protein O3 / O43524* / forkhead box O3*ENSMUSG0000004875644
Foxo4 / Q9WVH3 / Forkhead box protein O4 / P98177* / forkhead box O4*ENSMUSG0000004290334
Foxo6 / Q70KY4 / Forkhead box protein O6 / A8MYZ6* / forkhead box O6*ENSMUSG0000005213532
Foxm1 / forkhead box M1 / Q08050*ENSMUSG0000000151717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR032068  FOXO protein, KIX-binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0008286 insulin receptor signaling pathway IMP
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade IEA
 biological_processGO:0034599 cellular response to oxidative stress IDA
 biological_processGO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042593 glucose homeostasis IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation ISS
 biological_processGO:0045722 positive regulation of gluconeogenesis IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0070166 enamel mineralization IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071455 cellular response to hyperoxia IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071732 cellular response to nitric oxide IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0097150 neuronal stem cell population maintenance IGI
 biological_processGO:1902617 response to fluoride IEA
 biological_processGO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IGI
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IPI
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IGI
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0051721 protein phosphatase 2A binding IDA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA * FVB

 MP:0000263 absent organized vascular network "formation of vasculature, but failure to differentiate into stereotypic organized pattern" [J:53370]
Show

Allelic Composition: Raratm1Ipc/Rara+
Genetic Background: involves: 129S2/SvPas

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hsf4ldis1/Hsf4ldis1
Genetic Background: involves: C57BL/6 * CAST/EiJ * RIIIS/J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000687 small lymphoid organs "reduced size of lymphatic tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Mmp9tm1Tvu/Mmp9+
Genetic Background: B10.Cg-Mmp9tm1Tvu Dmdmdx

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Mmp9tm1Tvu/Mmp9+
Genetic Background: B10.Cg-Mmp9tm1Tvu Dmdmdx

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsf4ldis1/Hsf4ldis1
Genetic Background: involves: C57BL/6 * CAST/EiJ * RIIIS/J

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Raratm1Ipc/Rara+
Genetic Background: involves: 129S2/SvPas

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001749 suppressed circulating follicle stimulating hormone level "repression of secretion into the blood of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:45065, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002047 hepatic hemangioma "neoplastic- like masses in the liver; often undergoes spontaneous regression" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac,Leprdb/Leprdb
Genetic Background: B6.Cg-Foxo1tm2.1Dac Leprdb

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac,Insrtm1Dac/Insr+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo3tm1.1Rdp/Foxo3tm1.1Rdp,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Ifngtm1Ts/Ifngtm1Ts,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
Show

Allelic Composition: Foxo3tm1.1Rdp/Foxo3tm1.1Rdp,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxo1tm1Whb/Foxo1+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Raratm1Ipc/Rara+
Genetic Background: involves: 129S2/SvPas

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raratm1Ipc/Rara+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Raratm1Ipc/Rara+
Genetic Background: involves: 129S2/SvPas

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Raratm1Ipc/Rara+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: C57BL/6

Allelic Composition: Foxo1tm1.1Rdp/Foxo1+,Igh-Jtm1Cgn/Ightm4Cgn,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-Il7r)1Asin/?,Tg(Cd4-cre)1Cwi/?,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Irs1tm1Mfw/Irs1tm1Mfw,Irs2tm2Mfw/Irs2tm2Mfw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Krt33aPlsh-2Btlr/Krt33a+
Genetic Background: C57BL/6J-Krt33aPlsh-2Btlr

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac,Leprdb/Leprdb
Genetic Background: B6.Cg-Foxo1tm2.1Dac Leprdb

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Raratm1Ipc/Rara+
Genetic Background: involves: 129S2/SvPas

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac,Insrtm1Dac/Insr+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo1tm1Whb/Foxo1+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Foxo1tm1Whb/Foxo1+,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Raratm1Ipc/Rara+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0006345 absent second branchial arch "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Raratm1Ipc/Rara+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Ifngtm1Ts/Ifngtm1Ts,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Ifngtm1Ts/Ifngtm1Ts,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0008081 abnormal single-positive T cell number "anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13Hd/Hoxa13+,Tg(Prrx1-Sox9,-lacZ)1Haak/0
Genetic Background: involves: C57BL/6 * DBA/2 * MYA/Hu

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: HhatTg(TFAP2A-cre)1Will/Hhat+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0009328 delayed heart looping "late onset of the initiation and/or completion of cardiac looping" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1.1Stlp/Foxo1tm1.1Stlp,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJae

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0010306 increased hamartoma incidence "greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Myf6tm1(cre)Mrc/Myf6+,Pax3tm1Mrc/Pax3tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Foxo1tm1Tf/Foxo1tm1Tf
Genetic Background: involves: C57BL/6J

Allelic Composition: Foxo1tm1.1Rdp/Foxo1tm1.1Rdp
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Foxo1tm1.1Dac/Foxo1tm1.1Dac
Genetic Background: Not Specified

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0012492 branchial arch artery hypoplasia "underdevelopment or reduced size of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [MGI:anna]
Show

Allelic Composition: Foxo1tm1Tf/Foxo1tm1Tf
Genetic Background: involves: C57BL/6J

 MP:0012730 abnormal internal carotid artery morphology "any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes" [MGI:anna]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr