Manteia

ENSMUSG00000052135

Mus musculus

Features

Gene ID:	ENSMUSG00000052135

Biological name :	Foxo6

Synonyms :	Forkhead box protein O6 / Foxo6 / Q70KY4

Possible biological names infered from orthology :	A8MYZ6 / forkhead box O6

Species:	Mus musculus

Chr. number:	4
Strand:	-1
Band:	D2.1
Gene start:	120267079
Gene end:	120287349

Corresponding Affymetrix probe sets:	10515939 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000099716 NCBI entrez gene - 329934 See in Manteia. MGI - MGI:2676586 RefSeq - NM_194060 RefSeq Peptide - NP_918949 swissprot - Q70KY4 Ensembl - ENSMUSG00000052135

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
foxo6a	ENSDARG00000100486	Danio rerio
foxo6b	ENSDARG00000024619	Danio rerio
FOXO6	ENSGALG00000026153	Gallus gallus
FOXO6	ENSG00000204060	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Foxo3 / Q9WVH4 / Forkhead box protein O3 / O43524* / forkhead box O3*	ENSMUSG00000048756	43
Foxo1 / Q9R1E0 / Forkhead box protein O1 / Q12778* / forkhead box O1*	ENSMUSG00000044167	37
Foxo4 / Q9WVH3 / Forkhead box protein O4 / P98177* / forkhead box O4*	ENSMUSG00000042903	33
Foxm1 / forkhead box M1 / Q08050*	ENSMUSG00000001517	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR001766	Fork head domain
IPR030456	Fork head domain conserved site 2
IPR032067	FOXO protein, transactivation domain
IPR032068	FOXO protein, KIX-binding domain
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036390	Winged helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0007613	memory	IMP
biological_process	GO:0009653	anatomical structure morphogenesis	IBA
biological_process	GO:0060999	positive regulation of dendritic spine development	IMP
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Msx1^{tm2.1(cre/ERT2)Bero}/Msx1^{tm2.1(cre/ERT2)Bero},Msx2^tm1Bero/Msx2^tm1Bero Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0001441	increased grooming behavior	"increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Msx1^{tm2.1(cre/ERT2)Bero}/Msx1^{tm2.1(cre/ERT2)Bero},Msx2^tm1Bero/Msx2^tm1Bero Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0001468	abnormal temporal memory	"anomaly in the ability to recall temporal events and stimuli" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Msx1^{tm2.1(cre/ERT2)Bero}/Msx1^{tm2.1(cre/ERT2)Bero},Msx2^tm1Bero/Msx2^tm1Bero Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0002310	resistance to fatty liver development	"less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002801	abnormal long-term recognition memory	"defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Msx1^{tm2.1(cre/ERT2)Bero}/Msx1^{tm2.1(cre/ERT2)Bero},Msx2^tm1Bero/Msx2^tm1Bero Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0003383	abnormal gluconeogenesis	"anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0003799	impaired macrophage migration	"defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0004994	abnormal brain wave pattern	"any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Msx1^{tm2.1(cre/ERT2)Bero}/Msx1^{tm2.1(cre/ERT2)Bero},Msx2^tm1Bero/Msx2^tm1Bero Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0008114	abnormal Kupffer cell morphology	"any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0009133	decreased white fat cell size	"reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0009356	decreased liver triglyceride level	"lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0009936	abnormal dendritic spine morphology	"any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Msx1^{tm2.1(cre/ERT2)Bero}/Msx1^{tm2.1(cre/ERT2)Bero},Msx2^tm1Bero/Msx2^tm1Bero Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0010182	decreased susceptibility to weight gain	"smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0013278	decreased fasted circulating glucose level	"reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Piezo1^{tm1c(KOMP)Wtsi}/Piezo1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6J * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr