ENSMUSG00000042903


Mus musculus

Features
Gene ID: ENSMUSG00000042903
  
Biological name :Foxo4
  
Synonyms : Forkhead box protein O4 / Foxo4 / Q9WVH3
  
Possible biological names infered from orthology : forkhead box O4 / P98177
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 101254528
Gene end: 101260873
  
Corresponding Affymetrix probe sets: 10601091 (MoGene1.0st)   1422149_at (Mouse Genome 430 2.0 Array)   1456753_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059420
Ensembl peptide - ENSMUSP00000116165
NCBI entrez gene - 54601     See in Manteia.
MGI - MGI:1891915
RefSeq - NM_018789
RefSeq Peptide - NP_061259
swissprot - B1AUT3
swissprot - B1AUT2
swissprot - Q9WVH3
Ensembl - ENSMUSG00000042903
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxo4ENSDARG00000055792Danio rerio
 FOXO4ENSGALG00000005658Gallus gallus
 FOXO4ENSG00000184481Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxo1 / Q9R1E0 / Forkhead box protein O1 / Q12778* / forkhead box O1*ENSMUSG0000004416744
Foxo3 / Q9WVH4 / Forkhead box protein O3 / O43524* / forkhead box O3*ENSMUSG0000004875643
Foxo6 / Q70KY4 / Forkhead box protein O6 / A8MYZ6* / forkhead box O6*ENSMUSG0000005213536
Foxm1 / forkhead box M1 / Q08050*ENSMUSG0000000151719


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR032068  FOXO protein, KIX-binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest ISS
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway ISS
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048863 stem cell differentiation ISO
 biological_processGO:0051151 negative regulation of smooth muscle cell differentiation ISS
 biological_processGO:0070317 negative regulation of G0 to G1 transition ISO
 biological_processGO:0071158 positive regulation of cell cycle arrest ISO
 biological_processGO:1990785 response to water-immersion restraint stress IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Foxo1tm1.1Rdp/Foxo1tm1.1Rdp
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Foxo3tm1.1Rdp/Foxo3+,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Foxo1tm1.1Rdp/Foxo1tm1.1Rdp
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Foxo3tm1.1Rdp/Foxo3+,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

 MP:0002047 hepatic hemangioma "neoplastic- like masses in the liver; often undergoes spontaneous regression" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Foxo1tm1.1Rdp/Foxo1tm1.1Rdp
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo3tm1.1Rdp/Foxo3tm1.1Rdp,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo3Gt(VICTR20)1Kca/Foxo3Gt(VICTR20)1Kca
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1.1Rdp/Foxo3tm1.1Rdp,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo3tm1.1Rdp/Foxo3+,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J

 MP:0009442 ovarian teratoma "a usually benign tumor found in the ovary that is the result of an anomaly of oogenesis and typically contains a diversity of tissues often representing all organ systems e.g. hair, teeth, bone, thyroid, nerve tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo3tm1.1Rdp/Foxo3tm1.1Rdp,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

 MP:0010306 increased hamartoma incidence "greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1Rdp,Foxo3tm1Rdp/Foxo3tm1Rdp,Foxo4tm1Rdp/Foxo4tm1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

 MP:0012437 increased Harderian gland tumor incidence "greater than the expected number of neoplams in the Harderian gland, usually in the form of a distinct mass, in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Foxo3tm1.1Rdp/Foxo3tm1.1Rdp,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

Allelic Composition: Foxo3tm1.1Rdp/Foxo3+,Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction






 

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