ENSG00000111206


Homo sapiens

Features
Gene ID: ENSG00000111206
  
Biological name :FOXM1
  
Synonyms : forkhead box M1 / FOXM1 / Q08050
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.33
Gene start: 2857681
Gene end: 2877155
  
Corresponding Affymetrix probe sets: 202580_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444541
Ensembl peptide - ENSP00000442309
Ensembl peptide - ENSP00000486536
Ensembl peptide - ENSP00000342307
Ensembl peptide - ENSP00000352901
Ensembl peptide - ENSP00000354492
NCBI entrez gene - 2305     See in Manteia.
OMIM - 602341
RefSeq - XM_011520935
RefSeq - NM_001243089
RefSeq - NM_021953
RefSeq - NM_202002
RefSeq - NM_202003
RefSeq - XM_005253676
RefSeq - XM_011520930
RefSeq - XM_011520931
RefSeq - XM_011520932
RefSeq - XM_011520933
RefSeq - XM_011520934
RefSeq - NM_001243088
RefSeq Peptide - NP_973732
RefSeq Peptide - NP_973731
RefSeq Peptide - NP_001230017
RefSeq Peptide - NP_001230018
RefSeq Peptide - NP_068772
swissprot - Q53Y49
swissprot - H0YGS4
swissprot - Q08050
swissprot - H0YG99
swissprot - A0A0D9SFF0
Ensembl - ENSG00000111206
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxm1ENSDARG00000003200Danio rerio
 ENSGALG00000040734Gallus gallus
 FOXM1ENSGALG00000013420Gallus gallus
 Foxm1ENSMUSG00000001517Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXO3 / O43524 / forkhead box O3ENSG0000011868915
FOXO1 / Q12778 / forkhead box O1ENSG0000015090714
FOXO4 / P98177 / forkhead box O4ENSG0000018448112
FOXO6 / A8MYZ6 / forkhead box O6ENSG0000020406012


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IDA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046578 regulation of Ras protein signal transduction IMP
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:0071156 regulation of cell cycle arrest IMP
 biological_processGO:0090344 negative regulation of cell aging IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000781 positive regulation of double-strand break repair IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Polo-like kinase mediated events
Cyclin A/B1/B2 associated events during G2/M transition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101057 MYBL2 / P10244 / MYB proto-oncogene like 2  / reaction / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction / complex
 ENSG00000221914 P63151 / PPP2R2A / protein phosphatase 2 regulatory subunit Balpha  / reaction






 

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