ENSG00000101057


Homo sapiens

Features
Gene ID: ENSG00000101057
  
Biological name :MYBL2
  
Synonyms : MYBL2 / MYB proto-oncogene like 2 / P10244
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.12
Gene start: 43667019
Gene end: 43716496
  
Corresponding Affymetrix probe sets: 201710_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000217026
Ensembl peptide - ENSP00000380072
NCBI entrez gene - 4605     See in Manteia.
OMIM - 601415
RefSeq - NM_001278610
RefSeq - NM_002466
RefSeq Peptide - NP_001265539
RefSeq Peptide - NP_002457
swissprot - P10244
Ensembl - ENSG00000101057
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mybl2bENSDARG00000032264Danio rerio
 MYBL2ENSGALG00000003503Gallus gallus
 Mybl2ENSMUSG00000017861Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYBL1 / P10243 / MYB proto-oncogene like 1ENSG0000018569740
MYB / P10242 / MYB proto-oncogene, transcription factorENSG0000011851338
Q5SXM2 / SNAPC4 / small nuclear RNA activating complex polypeptide 4ENSG0000016568420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR015395  C-myb, C-terminal
 IPR017877  Myb-like domain
 IPR017930  Myb domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:0090307 mitotic spindle assembly IBA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0031523 Myb complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Polo-like kinase mediated events
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111206 FOXM1 / Q08050 / forkhead box M1  / reaction / complex






 

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