ENSG00000118513


Homo sapiens

Features
Gene ID: ENSG00000118513
  
Biological name :MYB
  
Synonyms : MYB / MYB proto-oncogene, transcription factor / P10242
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q23.3
Gene start: 135181315
Gene end: 135219173
  
Corresponding Affymetrix probe sets: 204798_at (Human Genome U133 Plus 2.0 Array)   215152_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434675
Ensembl peptide - ENSP00000434723
Ensembl peptide - ENSP00000479896
Ensembl peptide - ENSP00000477898
Ensembl peptide - ENSP00000437264
Ensembl peptide - ENSP00000437081
Ensembl peptide - ENSP00000436925
Ensembl peptide - ENSP00000436605
Ensembl peptide - ENSP00000436602
Ensembl peptide - ENSP00000436385
Ensembl peptide - ENSP00000435938
Ensembl peptide - ENSP00000435595
Ensembl peptide - ENSP00000435578
Ensembl peptide - ENSP00000435497
Ensembl peptide - ENSP00000435293
Ensembl peptide - ENSP00000435055
Ensembl peptide - ENSP00000434917
Ensembl peptide - ENSP00000434816
Ensembl peptide - ENSP00000434795
Ensembl peptide - ENSP00000326328
Ensembl peptide - ENSP00000339992
Ensembl peptide - ENSP00000341050
Ensembl peptide - ENSP00000356786
Ensembl peptide - ENSP00000356788
Ensembl peptide - ENSP00000390460
Ensembl peptide - ENSP00000403387
Ensembl peptide - ENSP00000410825
Ensembl peptide - ENSP00000413011
Ensembl peptide - ENSP00000432042
Ensembl peptide - ENSP00000432168
Ensembl peptide - ENSP00000432811
Ensembl peptide - ENSP00000432851
Ensembl peptide - ENSP00000432877
Ensembl peptide - ENSP00000432948
Ensembl peptide - ENSP00000433227
Ensembl peptide - ENSP00000433458
Ensembl peptide - ENSP00000433745
Ensembl peptide - ENSP00000433844
Ensembl peptide - ENSP00000434420
Ensembl peptide - ENSP00000434639
NCBI entrez gene - 4602     See in Manteia.
OMIM - 189990
RefSeq - NM_005375
RefSeq - NM_001130172
RefSeq - NM_001130173
RefSeq - NM_001161656
RefSeq - NM_001161657
RefSeq - NM_001161658
RefSeq - NM_001161659
RefSeq - NM_001161660
RefSeq Peptide - NP_005366
RefSeq Peptide - NP_001123644
RefSeq Peptide - NP_001123645
RefSeq Peptide - NP_001155128
RefSeq Peptide - NP_001155129
RefSeq Peptide - NP_001155130
RefSeq Peptide - NP_001155131
RefSeq Peptide - NP_001155132
swissprot - A0A087WTI6
swissprot - F8W8G5
swissprot - H0YCN6
swissprot - P10242
swissprot - Q708E1
swissprot - Q708E3
swissprot - Q708E5
swissprot - Q708E6
swissprot - Q708E8
swissprot - E9PQQ2
swissprot - Q708E9
swissprot - E9PPR4
swissprot - E9PPL8
swissprot - E9PP87
swissprot - E9PNH6
swissprot - E9PN92
swissprot - E9PN43
swissprot - E9PMZ0
swissprot - E9PMQ0
swissprot - E9PLN0
swissprot - E9PKZ3
swissprot - E9PJT2
swissprot - E9PJF1
swissprot - E9PJ96
swissprot - E9PIW4
swissprot - A0A0C4DG19
Ensembl - ENSG00000118513
  
Related genetic diseases (OMIM): 189990 - {T-cell acute lymphoblastic leukemia}

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mybENSDARG00000053666Danio rerio
 MYBENSGALG00000013956Gallus gallus
 MybENSMUSG00000019982Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYBL1 / P10243 / MYB proto-oncogene like 1ENSG0000018569744
MYBL2 / P10244 / MYB proto-oncogene like 2ENSG0000010105735
Q5SXM2 / SNAPC4 / small nuclear RNA activating complex polypeptide 4ENSG0000016568419


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR012642  Transcription regulator Wos2-domain
 IPR015395  C-myb, C-terminal
 IPR017877  Myb-like domain
 IPR017930  Myb domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000278 mitotic cell cycle IBA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045624 positive regulation of T-helper cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IMP
 biological_processGO:0051574 positive regulation of histone H3-K9 methylation IMP
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 biological_processGO:1904899 positive regulation of hepatic stellate cell proliferation IEA
 biological_processGO:2000491 positive regulation of hepatic stellate cell activation IEA
 biological_processGO:2000845 positive regulation of testosterone secretion IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016363 nuclear matrix NAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000169375 SIN3A / Q96ST3 / SIN3 transcription regulator family member A  / complex / reaction
 ENSG00000159216 RUNX1 / Q01196 / runt related transcription factor 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr