Manteia

ENSMUSG00000019982

Mus musculus

Features

Gene ID:	ENSMUSG00000019982

Biological name :	Myb

Synonyms :	Myb / P06876 / Transcriptional activator Myb

Possible biological names infered from orthology :	MYB proto-oncogene, transcription factor / P10242

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	A3
Gene start:	21124935
Gene end:	21160984

Corresponding Affymetrix probe sets:	10368199 (MoGene1.0st) 1421317_x_at (Mouse Genome 430 2.0 Array) 1422734_a_at (Mouse Genome 430 2.0 Array) 1450194_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000020158 Ensembl peptide - ENSMUSP00000139699 NCBI entrez gene - 17863 See in Manteia. MGI - MGI:97249 RefSeq - NM_001198914 RefSeq - NM_010848 RefSeq Peptide - NP_001185843 RefSeq Peptide - NP_034978 swissprot - P06876 swissprot - A0A087WPA7 Ensembl - ENSMUSG00000019982

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
myb	ENSDARG00000053666	Danio rerio
MYB	ENSGALG00000013956	Gallus gallus
MYB	ENSG00000118513	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mybl1 / MYB proto-oncogene like 1 / P10243*	ENSMUSG00000025912	44
Mybl2 / P48972 / Myb-related protein B / P10244* / MYB proto-oncogene like 2*	ENSMUSG00000017861	34
Q8BP86 / Snapc4 / snRNA-activating protein complex subunit 4 / Q5SXM2* / small nuclear RNA activating complex polypeptide 4*	ENSMUSG00000036281	17

Protein motifs (from Interpro)

Interpro ID	Name
IPR001005	SANT/Myb domain
IPR009057	Homeobox-like domain superfamily
IPR012642	Transcription regulator Wos2-domain
IPR015395	C-myb, C-terminal
IPR017930	Myb domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000082	G1/S transition of mitotic cell cycle	IMP
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0001666	response to hypoxia	IEA
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0006338	chromatin remodeling	ISO
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IMP
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0006816	calcium ion transport	IMP
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0017145	stem cell division	IMP
biological_process	GO:0030099	myeloid cell differentiation	IMP
biological_process	GO:0030183	B cell differentiation	IMP
biological_process	GO:0032967	positive regulation of collagen biosynthetic process	IEA
biological_process	GO:0043525	positive regulation of neuron apoptotic process	IEA
biological_process	GO:0045624	positive regulation of T-helper cell differentiation	ISO
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISO
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	ISO
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0048536	spleen development	IMP
biological_process	GO:0048538	thymus development	IMP
biological_process	GO:0048566	embryonic digestive tract development	IMP
biological_process	GO:0048661	positive regulation of smooth muscle cell proliferation	IEA
biological_process	GO:0048872	homeostasis of number of cells	IMP
biological_process	GO:0051571	positive regulation of histone H3-K4 methylation	ISO
biological_process	GO:0051574	positive regulation of histone H3-K9 methylation	ISO
biological_process	GO:0060252	positive regulation of glial cell proliferation	IEA
biological_process	GO:0070301	cellular response to hydrogen peroxide	IEA
biological_process	GO:0071300	cellular response to retinoic acid	IEA
biological_process	GO:0071354	cellular response to interleukin-6	IDA
biological_process	GO:0071636	positive regulation of transforming growth factor beta production	IEA
biological_process	GO:1901216	positive regulation of neuron death	IEA
biological_process	GO:1904899	positive regulation of hepatic stellate cell proliferation	IEA
biological_process	GO:1990830	cellular response to leukemia inhibitory factor	IEP
biological_process	GO:2000491	positive regulation of hepatic stellate cell activation	IEA
biological_process	GO:2000845	positive regulation of testosterone secretion	IEA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005829	cytosol	IDA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting	IBA
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IMP
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0071987	WD40-repeat domain binding	IDA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000222	decreased neutrophil count	"fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0000228	abnormal thrombopoiesis	"abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb⁺ Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb⁺ Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000229	abnormal megakaryocyte differentiation	"atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb⁺ Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb⁺ Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
MP:0000239	deficiency of myeloid colony forming progenitor cells	"lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI Allelic Composition: Myb^tm1Jof/Myb^tm1Jof Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Myb^tm1Jof/Myb^tm1Ssp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Myb^tm1Ssp/Myb^tm1Ssp Genetic Background: involves: 129S2/SvPas Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0000248	macrocytosis	"condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
MP:0000260	abnormal angiogenesis	"aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Myb^tm1Ssp/Myb^tm1Ssp Genetic Background: involves: 129S2/SvPas
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Mmachc^{tm1.1(NCOM)Mfgc}/Mmachc^{tm1.1(NCOM)Mfgc} Genetic Background: C57BL/6N-Mmachc^{tm1.1(NCOM)Mfgc}/Tcp
MP:0000321	increased bone marrow cell number	"increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Snta1^tm1Scf/Snta1^tm1Scf,Sntb2^tm1Maad/Sntb2^tm1Maad Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000596	abnormal liver development	"anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ephb1^tm1Cmn/Ephb1^tm2Cmn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Myb^tm1Jof/Myb^tm1Ssp Genetic Background: involves: 129/Sv * C57BL/6
MP:0000601	small liver	"reduced size of the liver" [J:23170]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Adarb1^tm1Phs/Adarb1^tm1Phs,Gria2^tm1.1Phs/Gria2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ephb1^tm1Cmn/Ephb1^tm2Cmn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Myb^tm1Jof/Myb^tm1Ssp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6 Allelic Composition: Ep300^tm1Pkb/Ep300⁺,Myb^tm1Ssp/Myb⁺ Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Ephb1^tm1Cmn/Ephb1^tm2Cmn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Myb^tm1.1Cgn/Myb^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6 Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0001802	arrested B cell development	"inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]	Show Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6 Allelic Composition: Myb^tm1.1Cgn/Myb⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Myb^tm1.1Cgn/Myb^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Myb^tm1Epr/Myb^tm1Epr,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Myb^tm1Epr/Myb^tm1Epr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0001825	arrested T cell development	"failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ephb1^tm1Cmn/Ephb1^tm2Cmn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ephb1^tm1Cmn/Ephb1^tm2Cmn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Myb^tm1Jof/Myb^tm1Ssp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb⁺ Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb⁺ Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Myb^tm1Ssp/Myb^tm1Ssp Genetic Background: involves: 129S2/SvPas Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ephb1^tm1Cmn/Ephb1^tm2Cmn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ephb1^tm1Cmn/Ephb1^tm2Cmn Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Myb^tm1Jof/Myb^tm1Ssp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Myb^tm1Epr/Myb^tm1Epr,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Myb^tm1Epr/Myb^tm1Epr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Myb^tm1.1Cgn/Myb^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Myb^tm1.1Jof/Myb^tm1.1Jof Genetic Background: involves: 129/Sv * C57BL/6
MP:0002407	abnormal double-negative T cell	"anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Myb^tm1Jof/Myb^tm1Jof Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Myb^tm1Epr/Myb^tm1Epr,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0002414	abnormal myeloblast morphology/development	"anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myb^tm1Jof/Myb^tm1Jof Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Myb^tm1Jof/Myb^tm1Ssp Genetic Background: involves: 129/Sv * C57BL/6
MP:0002417	abnormal megakaryocyte morphology/development	"anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ep300^tm1Pkb/Ep300⁺,Myb^tm1Ssp/Myb⁺ Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0002447	abnormal erythrocyte morphology	"structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
MP:0003405	abnormal platelet shape		Show Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0004229	abnormal embryonic erythropoiesis	"anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0004808	abnormal hematopoietic stem cell morphology	"any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^tm1Ssp/Myb^tm1Ssp Genetic Background: involves: 129S2/SvPas
MP:0004809	increased hematopoietic stem cell number	"greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6 Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0004978	decreased B-1 B cell number	"reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^tm1.1Cgn/Myb⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005012	decreased eosinophil count	"fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
MP:0005089	decreased double-negative T cell count	"reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Myb^tm1.1Cgn/Myb^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Myb^tm1Epr/Myb^tm1Epr,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Myb^tm1Epr/Myb^tm1Epr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0005097	polychromatophilia	"condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0005505	increased platelet count	"greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb⁺ Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb⁺ Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6 Allelic Composition: Ep300^tm1Pkb/Ep300⁺,Myb^tm1Ssp/Myb⁺ Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^tm1.1Cgn/Myb^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)548Jxm/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Myb^tm1Epr/Myb^tm1Epr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^tm1Epr/Myb^tm1Epr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0008083	decreased single-positive T cell number	"reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^M303V/Myb^M303V Genetic Background: involves: 129S1/SvlmJ * C57BL/6
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^tm1.1Cgn/Myb⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Myb^tm1.1Cgn/Myb⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008246	abnormal leukocyte morphology	"any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0008249	abnormal common lymphocyte progenitor cell morphology	"any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0008254	increased megakaryocyte cell number	"greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]	Show Allelic Composition: Myb^tm1Jof/Myb^tm1Jof Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Myb^tm1Jof/Myb^tm1Ssp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0008347	decreased gamma-delta T cell number	"reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Myb^tm1Cgn/Myb^tm1Cgn,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt4/Myb^Plt4 Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0008479	decreased spleen white pulp amount	"reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0008813	decreased common myeloid progenitor cell number	"reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0008989	abnormal liver sinusoid morphology	"any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0009395	persistence of primitive erythrocytes	"presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0010178	increased number of Howell-Jolly bodies	"abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myb^boo/Myb^boo Genetic Background: involves: C57BL/6
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Myb^Plt3/Myb^Plt3 Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI Allelic Composition: Myb^tm1Jof/Myb^tm1Ssp Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Myb^tm1.1Cgn/Myb^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Enho^tm1.1Butl/Enho⁺ Genetic Background: B6.Cg-Enho^tm1.1Butl

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

0 s.

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