Manteia

ENSMUSG00000025912

Mus musculus

Features

Gene ID:	ENSMUSG00000025912

Biological name :	Mybl1

Synonyms :	Mybl1 / MYB proto-oncogene like 1

Possible biological names infered from orthology :	P10243

Species:	Mus musculus

Chr. number:	1
Strand:	-1
Band:	A2
Gene start:	9667415
Gene end:	9700209

Corresponding Affymetrix probe sets:	10353010 (MoGene1.0st) 1450481_at (Mouse Genome 430 2.0 Array) 1456951_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000086034 Ensembl peptide - ENSMUSP00000139818 Ensembl peptide - ENSMUSP00000111128 NCBI entrez gene - 17864 See in Manteia. MGI - MGI:99925 RefSeq - XM_011238349 RefSeq - NM_001290397 RefSeq - NM_008651 RefSeq - XM_006495461 RefSeq Peptide - NP_001277326 RefSeq Peptide - NP_032677 swissprot - E9QLX9 swissprot - A0A0R4J132 swissprot - A0A087WPK9 Ensembl - ENSMUSG00000025912

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mybl1	ENSDARG00000030999	Danio rerio
MYBL1	ENSGALG00000033304	Gallus gallus
MYBL1	ENSG00000185697	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Myb / P06876 / Transcriptional activator Myb / P10242* / MYB proto-oncogene, transcription factor*	ENSMUSG00000019982	44
Mybl2 / P48972 / Myb-related protein B / P10244* / MYB proto-oncogene like 2*	ENSMUSG00000017861	36
Q8BP86 / Snapc4 / snRNA-activating protein complex subunit 4 / Q5SXM2* / small nuclear RNA activating complex polypeptide 4*	ENSMUSG00000036281	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR001005	SANT/Myb domain
IPR009057	Homeobox-like domain superfamily
IPR012642	Transcription regulator Wos2-domain
IPR015395	C-myb, C-terminal
IPR017930	Myb domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mybl1^repro9/Mybl1^repro9 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J Allelic Composition: Mybl1^repro9/Mybl1^repro9 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0001211	wrinkled skin	"irregular folds and/or indentations on the skin" [J:19212]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0001382	abnormal nursing	"females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0001800	abnormal humoral immune response	"abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J Allelic Composition: Mybl1^repro9/Mybl1^repro9 Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Mybl1^repro9/Mybl1^tm1Epr Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cmah^tm1Ykoz/Cmah^tm1Ykoz Genetic Background: B6.129P2-Cmah^tm1Ykoz
MP:0002362	abnormal spleen marginal zone morphology	"anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0002784	abnormal Sertoli cell morphology	"malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0004901	decreased male germ cell number	"reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J Allelic Composition: Mybl1^repro9/Mybl1^repro9 Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Mybl1^repro9/Mybl1^tm1Epr Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0006269	abnormal mammary gland growth during pregnancy	"anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0006270	abnormal mammary gland growth during lactation	"anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0006379	abnormal spermatocyte morphology	"anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0008261	arrest of male meiosis	"cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J Allelic Composition: Mybl1^repro9/Mybl1^repro9 Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Mybl1^repro9/Mybl1^tm1Epr Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0008280	male germ cell apoptosis	"presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J Allelic Composition: Mybl1^repro9/Mybl1^repro9 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0008482	decreased spleen germinal center number	"reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0008496	decreased IgG2a level	"less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0008498	decreased IgG3 level	"less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0009452	abnormal synaptonemal complex	"an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J Allelic Composition: Mybl1^repro9/Mybl1^repro9 Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Mybl1^repro9/Mybl1^tm1Epr Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0009504	abnormal mammary gland epithelium morphology	"any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq2^Nmf134/Kcnq2⁺ Genetic Background: C57BL/6J-Kcnq2^Nmf134/J
MP:0010948	abnormal double-strand DNA break repair	"any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]	Show Allelic Composition: Mybl1^repro9/Mybl1^repro9 Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr