ENSMUSG00000017861


Mus musculus

Features
Gene ID: ENSMUSG00000017861
  
Biological name :Mybl2
  
Synonyms : Mybl2 / Myb-related protein B / P48972
  
Possible biological names infered from orthology : MYB proto-oncogene like 2 / P10244
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H2
Gene start: 163054687
Gene end: 163084688
  
Corresponding Affymetrix probe sets: 10478355 (MoGene1.0st)   1417656_at (Mouse Genome 430 2.0 Array)   1454946_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018005
Ensembl peptide - ENSMUSP00000114710
NCBI entrez gene - 17865     See in Manteia.
MGI - MGI:101785
RefSeq - XM_006498878
RefSeq - NM_008652
RefSeq - XM_006498873
RefSeq - XM_006498875
RefSeq - XM_006498876
RefSeq Peptide - NP_032678
swissprot - P48972
swissprot - A2A5P3
Ensembl - ENSMUSG00000017861
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mybl2bENSDARG00000032264Danio rerio
 MYBL2ENSGALG00000003503Gallus gallus
 MYBL2ENSG00000101057Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mybl1 / MYB proto-oncogene like 1 / P10243*ENSMUSG0000002591238
Myb / P06876 / Transcriptional activator Myb / P10242* / MYB proto-oncogene, transcription factor*ENSMUSG0000001998236
Q8BP86 / Snapc4 / snRNA-activating protein complex subunit 4 / Q5SXM2* / small nuclear RNA activating complex polypeptide 4*ENSMUSG0000003628117


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR015395  C-myb, C-terminal
 IPR017930  Myb domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0090307 mitotic spindle assembly IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0031523 Myb complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srpk3tm1Eno/Y
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgm2tm1.1Rmgr/Tgm2+,Tg(HDexon1)62Gpb/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Srpk3tm1Eno/Y
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6J)

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
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Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0010178 increased number of Howell-Jolly bodies "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Tgm2tm1.1Rmgr/Tgm2+,Tg(HDexon1)62Gpb/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Srpk3tm1Eno/Y
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0011180 abnormal hematopoietic cell number "any anomaly in the expected number of cells of the hematopoietic lineage" [CL:0000988, MGI:csmith]
Show

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0011903 decreased hematopoietic stem cell proliferation "reduction in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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