ENSG00000221914


Homo sapiens

Features
Gene ID: ENSG00000221914
  
Biological name :PPP2R2A
  
Synonyms : P63151 / PPP2R2A / protein phosphatase 2 regulatory subunit Balpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.2
Gene start: 26291491
Gene end: 26372680
  
Corresponding Affymetrix probe sets: 202313_at (Human Genome U133 Plus 2.0 Array)   228013_at (Human Genome U133 Plus 2.0 Array)   236492_at (Human Genome U133 Plus 2.0 Array)   237636_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370113
Ensembl peptide - ENSP00000491731
Ensembl peptide - ENSP00000430320
Ensembl peptide - ENSP00000429279
Ensembl peptide - ENSP00000428800
Ensembl peptide - ENSP00000428705
Ensembl peptide - ENSP00000428542
Ensembl peptide - ENSP00000428165
Ensembl peptide - ENSP00000428164
Ensembl peptide - ENSP00000325074
NCBI entrez gene - 5520     See in Manteia.
OMIM - 604941
RefSeq - XM_011544569
RefSeq - XM_011544568
RefSeq - XM_011544567
RefSeq - XM_011544566
RefSeq - XM_011544565
RefSeq - XM_005273560
RefSeq - NM_001177591
RefSeq - XM_005273559
RefSeq - NM_002717
RefSeq Peptide - NP_001171062
RefSeq Peptide - NP_002708
swissprot - P63151
swissprot - E5RJV2
swissprot - A0A140VJT0
swissprot - A0A1W2PQI2
swissprot - E5RFR9
swissprot - E5RHQ2
swissprot - E5RIY1
swissprot - E5RJV1
Ensembl - ENSG00000221914
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r2aaENSDARG00000021996Danio rerio
 ppp2r2abENSDARG00000006624Danio rerio
 PPP2R2AENSGALG00000000235Gallus gallus
 Q6P1F6ENSMUSG00000022052Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q66LE6 / PPP2R2D / protein phosphatase 2 regulatory subunit BdeltaENSG0000017547085
Q00005 / PPP2R2B / protein phosphatase 2 regulatory subunit BbetaENSG0000015647582
Q9Y2T4 / PPP2R2C / protein phosphatase 2 regulatory subunit BgammaENSG0000007421177


Protein motifs (from Interpro)
Interpro ID Name
 IPR000009  Protein phosphatase 2A regulatory subunit PR55
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR018067  Protein phosphatase 2A regulatory subunit PR55, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000278 mitotic cell cycle IBA
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0007084 mitotic nuclear envelope reassembly TAS
 biological_processGO:0032502 developmental process IBA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0070262 peptidyl-serine dephosphorylation IBA
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
Initiation of Nuclear Envelope Reformation
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113575 P67775 / PPP2CA / protein phosphatase 2 catalytic subunit alpha  / complex
 ENSG00000105568 P30153 / PPP2R1A / protein phosphatase 2 scaffold subunit Aalpha  / complex
 ENSG00000111206 FOXM1 / Q08050 / forkhead box M1  / reaction
 ENSG00000175334 BANF1 / O75531 / barrier to autointegration factor 1  / reaction






 

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