ENSGALG00000004743


Gallus gallus

Features
Gene ID: ENSGALG00000004743
  
Biological name :MAPKAPK5
  
Synonyms : MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5
  
Possible biological names infered from orthology : Gm42878 / MAP kinase-activated protein kinase 5 / O54992 / Q8IW41
  
Species: Gallus gallus
  
Chr. number: 15
Strand: 1
Band:
Gene start: 6273634
Gene end: 6293093
  
Corresponding Affymetrix probe sets: Gga.4024.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007550
NCBI entrez gene - 373929     See in Manteia.
RefSeq - NM_001199807
RefSeq - XM_015275130
RefSeq Peptide - NP_001186736
swissprot - F1NHB6
Ensembl - ENSGALG00000004743
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkapk5ENSDARG00000028082Danio rerio
 Q8IW41ENSG00000089022Homo sapiens
 Gm42878ENSMUSG00000105340Mus musculus
 O54992ENSMUSG00000029454Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2 / P49137* / P49138* / MAP kinase-activated protein kinase 2 *ENSGALG0000000088334
MAPKAPK3 / Gallus gallus mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3), mRNA. / Q16644* / Q3UMW7* / MAP kinase-activated protein kinase 3 * / mitogen-activated prot...ENSGALG0000000228333
MKNK2 / MAP kinase interacting serine/threonine kinase 2 / Q8CDB0* / Q9HBH9* / MAP kinase-interacting serine/threonine-protein kinase 2 *ENSGALG0000000384525
MKNK1 / MAP kinase interacting serine/threonine kinase 1 / Q9BUB5*ENSGALG0000001044024


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0090400 stress-induced premature senescence IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / complex
 ENSGALG00000031448 MAPK6 / Q5F3W3 / Mitogen-activated protein kinase 6 / Q16659* / Q61532*  / reaction / complex
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSGALG00000010551 CDC42EP3 / CDC42 effector protein 3 / Q9CQC5* / Q9UKI2*  / reaction
 ENSGALG00000015297 FOXO3 / forkhead box O3 / O43524* / Q9WVH4* / Forkhead box protein O3 *  / reaction
 ENSGALG00000004370 MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*  / reaction
 ENSGALG00000041285 MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*  / reaction






 

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