ENSGALG00000004370


Gallus gallus

Features
Gene ID: ENSGALG00000004370
  
Biological name :MAP2K6
  
Synonyms : MAP2K6 / mitogen-activated protein kinase kinase 6
  
Possible biological names infered from orthology : P52564 / P70236
  
Species: Gallus gallus
  
Chr. number: 18
Strand: 1
Band:
Gene start: 8052645
Gene end: 8088396
  
Corresponding Affymetrix probe sets: Gga.13002.1.S1_at (Chicken Array)   GgaAffx.26190.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006960
Ensembl peptide - ENSGALP00000064623
Ensembl peptide - ENSGALP00000052316
NCBI entrez gene - 417445     See in Manteia.
RefSeq - XM_003642348
RefSeq - XM_004946240
swissprot - A0A1L1S0H7
swissprot - A0A1D5PHN6
swissprot - F1NVF2
Ensembl - ENSGALG00000004370
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k6ENSDARG00000099184Danio rerio
 MAP2K6ENSG00000108984Homo sapiens
 Map2k6ENSMUSG00000020623Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*ENSGALG0000004128580
MAP2K4 / mitogen-activated protein kinase kinase 4 / P45985* / P47809* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSGALG0000003217855
MAP2K5 / dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / Q9WVS7* / mitogen-activated protein kinase kinase 5*ENSGALG0000000793039
MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *ENSGALG0000000768738
MAP2K2 / dual specificity mitogen-activated protein kinase kinase 2 / P36507* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein ...ENSGALG0000000126737


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0060048 cardiac muscle contraction IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Oxidative Stress Induced Senescence
activated TAK1 mediates p38 MAPK activation
PI5P Regulates TP53 Acetylation
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000040023 MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / reaction
 ENSGALG00000004743 MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41* / O54992* / Gm42878* / MAP kinase-activated protein kinase 5 *  / reaction
 ENSGALG00000001610 PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 beta / P78356* / Q80XI4*  / reaction
 ENSGALG00000042833 MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*  / reaction
 ENSGALG00000000883 MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2 / P49137* / P49138* / MAP kinase-activated protein kinase 2 *  / reaction
 ENSGALG00000002283 MAPKAPK3 / Gallus gallus mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3), mRNA. / Q16644* / Q3UMW7* / MAP kinase-activated protein kinase 3 * / mitogen-activated prot...  / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / reaction
 ENSGALG00000013892 MAP3K5 / mitogen-activated protein kinase kinase kinase 5 / O35099* / Q99683*  / reaction






 

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