ENSGALG00000007687


Gallus gallus

Features
Gene ID: ENSGALG00000007687
  
Biological name :MAP2K1
  
Synonyms : MAP2K1 / mitogen-activated protein kinase kinase 1
  
Possible biological names infered from orthology : Dual specificity mitogen-activated protein kinase kinase 1 / P31938 / Q02750
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 18493690
Gene end: 18525242
  
Corresponding Affymetrix probe sets: Gga.1443.1.S1_s_at (Chicken Array)   Gga.1443.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060719
Ensembl peptide - ENSGALP00000012448
Ensembl peptide - ENSGALP00000050365
NCBI entrez gene - 415549     See in Manteia.
RefSeq - XM_015292096
RefSeq - NM_001005830
RefSeq Peptide - NP_001005830
swissprot - A0A1L1RPJ2
swissprot - Q5ZIF0
swissprot - F7BAQ9
Ensembl - ENSGALG00000007687
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k1ENSDARG00000007825Danio rerio
 MAP2K1ENSG00000169032Homo sapiens
 Map2k1ENSMUSG00000004936Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K2 / dual specificity mitogen-activated protein kinase kinase 2 / P36507* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein ...ENSGALG0000000126783
MAP2K5 / dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / Q9WVS7* / mitogen-activated protein kinase kinase 5*ENSGALG0000000793036
MAP2K4 / mitogen-activated protein kinase kinase 4 / P45985* / P47809* / Dual specificity mitogen-activated protein kinase kinase 4 *ENSGALG0000003217834
MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*ENSGALG0000004128532
MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*ENSGALG0000000437032


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0021697 cerebellar cortex formation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048679 regulation of axon regeneration IEA
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0060020 Bergmann glial cell differentiation IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060440 trachea formation IEA
 biological_processGO:0060502 epithelial cell proliferation involved in lung morphogenesis IEA
 biological_processGO:0060674 placenta blood vessel development IEA
 biological_processGO:0060711 labyrinthine layer development IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090398 cellular senescence IEA
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0004728 obsolete signal transducer, downstream of receptor, with protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
MAPK3 (ERK1) activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000055 Q5ZIP2 / LAMTOR3 / Ragulator complex protein LAMTOR3 / O88653* / Q9UHA4* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3*  / complex / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000003085 CDK1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex
 ENSGALG00000011505 MARK3 / microtubule affinity regulating kinase 3 / P27448* / Q03141* / MAP/microtubule affinity-regulating kinase 3 *  / complex / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / reaction / complex
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSGALG00000029881 LAMTOR2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 / Q9JHS3* / Q9Y2Q5* / Ragulator complex protein LAMTOR2 *  / reaction / complex
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / complex / reaction






 

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