ENSGALG00000032178


Gallus gallus

Features
Gene ID: ENSGALG00000032178
  
Biological name :MAP2K4
  
Synonyms : MAP2K4 / mitogen-activated protein kinase kinase 4
  
Possible biological names infered from orthology : Dual specificity mitogen-activated protein kinase kinase 4 / P45985 / P47809
  
Species: Gallus gallus
  
Chr. number: 18
Strand: 1
Band:
Gene start: 735926
Gene end: 823504
  
Corresponding Affymetrix probe sets: GgaAffx.644.1.S1_at (Chicken Array)   GgaAffx.644.2.S1_at (Chicken Array)   GgaAffx.644.2.S1_s_at (Chicken Array)   GgaAffx.644.2.S1_x_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044416
Ensembl peptide - ENSGALP00000046884
NCBI entrez gene - 417312     See in Manteia.
RefSeq - XM_015295237
RefSeq - XM_015295238
RefSeq - XM_015295239
RefSeq - XM_015295240
swissprot - A0A1D5P2I9
swissprot - A0A1D5NVP0
Ensembl - ENSGALG00000032178
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k4aENSDARG00000063583Danio rerio
 map2k4bENSDARG00000077177Danio rerio
 MAP2K4ENSG00000065559Homo sapiens
 Map2k4ENSMUSG00000033352Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*ENSGALG0000000437043
MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*ENSGALG0000004128541
MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *ENSGALG0000000768731
MAP2K2 / dual specificity mitogen-activated protein kinase kinase 2 / P36507* / Q63932* / AC011005.1* / mitogen-activated protein kinase kinase 2* / Mus musculus mitogen-activated protein ...ENSGALG0000000126731
MAP2K5 / dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / Q9WVS7* / mitogen-activated protein kinase kinase 5*ENSGALG0000000793029


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:2000672 negative regulation of motor neuron apoptotic process IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014718 MAP3K1 / mitogen-activated protein kinase kinase kinase 1 / Q13233*  / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / reaction
 ENSGALG00000011109 MAPK10 / Gallus gallus mitogen-activated protein kinase 10 (MAPK10), transcript variant 1, mRNA. / P53779* / mitogen-activated protein kinase 10* / mitogen-activated protein kinase 10 isoform 1x *  / reaction
 ENSGALG00000039099 MAPK9 / P79996 / Mitogen-activated protein kinase 9 / P45984* / Q9WTU6*  / reaction
 ENSGALG00000006109 MAPK8 / mitogen-activated protein kinase 8 / P45983* / Q91Y86*  / reaction






 

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