ENSGALG00000006109


Gallus gallus

Features
Gene ID: ENSGALG00000006109
  
Biological name :MAPK8
  
Synonyms : MAPK8 / mitogen-activated protein kinase 8
  
Possible biological names infered from orthology : P45983 / Q91Y86
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 18235847
Gene end: 18278189
  
Corresponding Affymetrix probe sets: Gga.1147.1.S1_at (Chicken Array)   Gga.1147.1.S1_s_at (Chicken Array)   GgaAffx.3808.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009848
Ensembl peptide - ENSGALP00000058031
NCBI entrez gene - 423778     See in Manteia.
RefSeq - XM_015288441
RefSeq - XM_015288439
RefSeq - XM_015288440
RefSeq - XM_001233168
RefSeq - XM_004942132
RefSeq - XM_004942133
swissprot - E1C1H4
swissprot - A0A1D5PYH8
Ensembl - ENSGALG00000006109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPK8ENSG00000107643Homo sapiens
 Mapk8ENSMUSG00000021936Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK10 / Gallus gallus mitogen-activated protein kinase 10 (MAPK10), transcript variant 1, mRNA. / P53779* / mitogen-activated protein kinase 10* / mitogen-activated protein kinase 10 isoform 1x *ENSGALG0000001110990
MAPK9 / P79996 / Mitogen-activated protein kinase 9 / P45984* / Q9WTU6*ENSGALG0000003909983
MAPK11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*ENSGALG0000004002346
MAPK12 / mitogen-activated protein kinase 12 / O08911* / P53778*ENSGALG0000001938444
MAPK13 / mitogen-activated protein kinase 13 / O15264* / Q9Z1B7*ENSGALG0000003096637
MAPK14 / mitogen-activated protein kinase 14 / P47811* / Q16539*ENSGALG0000004283324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008351  Mitogen-activated protein (MAP) kinase, JNK
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0007258 JUN phosphorylation IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0009612 response to mechanical stimulus IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0031063 regulation of histone deacetylation IEA
 biological_processGO:0031281 positive regulation of cyclase activity IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0051247 positive regulation of protein metabolic process IEA
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071310 cellular response to organic substance IBA
 biological_processGO:0090045 positive regulation of deacetylase activity IEA
 biological_processGO:1902595 regulation of DNA replication origin binding IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004705 JUN kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035033 histone deacetylase regulator activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA


Pathways (from Reactome)
Pathway description
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
DSCAM interactions
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction
 ENSGALG00000014537 BMF / bcl-2-modifying factor / Q96LC9* / Mus musculus BCL2 modifying factor (Bmf), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000005522 DYNLL2 / dynein light chain LC8-type 2 / Q96FJ2* / Q9D0M5* / Dynein light chain 2, cytoplasmic *  / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000032178 MAP2K4 / mitogen-activated protein kinase kinase 4 / P45985* / P47809* / Dual specificity mitogen-activated protein kinase kinase 4 *  / reaction
 ENSGALG00000042491 P62801 / Histone H4   / reaction / complex
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction






 

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