ENSGALG00000017159


Gallus gallus

Features
Gene ID: ENSGALG00000017159
  
Biological name :ATM
  
Synonyms : ATM / ATM serine/threonine kinase
  
Possible biological names infered from orthology : Q13315 / Q62388 / Serine-protein kinase ATM
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 180285849
Gene end: 180345559
  
Corresponding Affymetrix probe sets: Gga.2138.1.S1_at (Chicken Array)   GgaAffx.10998.1.S1_at (Chicken Array)   GgaAffx.10999.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027660
NCBI entrez gene - 395401     See in Manteia.
RefSeq - NM_001162400
RefSeq - XM_015277571
RefSeq - XM_015277574
RefSeq Peptide - NP_001155872
swissprot - E1C0Q6
Ensembl - ENSGALG00000017159
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atmENSDARG00000002385Danio rerio
 ATMENSG00000149311Homo sapiens
 AtmENSMUSG00000034218Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR011009  Protein kinase-like domain superfamily
 IPR014009  PIK-related kinase
 IPR015519  Serine/threonine-protein kinase ATM
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR021668  Telomere-length maintenance and DNA damage repair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0002331 pre-B cell allelic exclusion IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002377 immunoglobulin production IEA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006975 DNA damage induced protein phosphorylation IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0007140 male meiotic nuclear division IEA
 biological_processGO:0007143 female meiotic nuclear division IEA
 biological_processGO:0007292 female gamete generation IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008340 determination of adult lifespan IEA
 biological_processGO:0008585 female gonad development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0032210 regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0033151 V(D)J recombination IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IEA
 biological_processGO:0042159 lipoprotein catabolic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045141 meiotic telomere clustering IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048599 oocyte development IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IEA
 biological_processGO:0071044 histone mRNA catabolic process IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:0071500 cellular response to nitrosative stress IEA
 biological_processGO:0072434 signal transduction involved in mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0090399 replicative senescence IEA
 biological_processGO:0097694 establishment of RNA localization to telomere IEA
 biological_processGO:1904262 negative regulation of TORC1 signaling IEA
 biological_processGO:1904354 negative regulation of telomere capping IEA
 biological_processGO:1904358 positive regulation of telomere maintenance via telomere lengthening IEA
 biological_processGO:1904884 positive regulation of telomerase catalytic core complex assembly IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:1990391 DNA repair complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004677 DNA-dependent protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IBA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage/Telomere Stress Induced Senescence
Autodegradation of the E3 ubiquitin ligase COP1
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of Caspase Activators and Caspases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2/M DNA damage checkpoint
Stabilization of p53


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / reaction / complex
 ENSGALG00000000777 EYA3 / EYA transcriptional coactivator and phosphatase 3 / P97480* / Q99504* / Eyes absent homolog 3 *  / reaction
 ENSGALG00000002663 ATR / ATR serine/threonine kinase / Q13535*  / reaction / complex
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / reaction / complex
 ENSGALG00000004037 DNA2 / Q5ZKG3 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / Q6ZQJ5* / DNA replication helicase...  / complex / reaction
 ENSGALG00000005028 TOP3A / DNA topoisomerase 3-alpha isoform 1 / O70157* / Q13472* / DNA topoisomerase III alpha* / topoisomerase (DNA) III alpha*  / complex / reaction
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / complex / reaction
 ENSGALG00000007155 RMI2 / Q5ZM20 / RecQ-mediated genome instability protein 2 / Q96E14* / Q3UPE3* / RecQ mediated genome instability 2*  / complex / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000005695 CHEK2 / checkpoint kinase 2 / O96017* / Q9Z265* / Serine/threonine-protein kinase Chk2 *  / complex / reaction
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSGALG00000010748 EXO1 / exonuclease 1 / Q9QZ11* / Q9UQ84*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000042523 EYA2* / O00167* / O08575* / Eyes absent homolog 2 * / EYA transcriptional coactivator and phosphatase 2*  / reaction
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSGALG00000009942 MDM2 / MDM2 proto-oncogene / P23804* / Q00987* / E3 ubiquitin-protein ligase Mdm2 *  / reaction
 ENSGALG00000012484 RIF1 / E1C2U2 / Telomere-associated protein RIF1 / Q6PR54* / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSGALG00000006109 MAPK8 / mitogen-activated protein kinase 8 / P45983* / Q91Y86*  / reaction / complex
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex
 ENSGALG00000040729 PIDD1 / p53-induced death domain protein 1 / Q9ERV7* / Q9HB75* / p53-induced death domain-containing protein 1 *  / reaction
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / complex / reaction
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex
 ENSGALG00000015705 NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / complex / reaction
 ENSGALG00000004500 COP1 / COP1, E3 ubiquitin ligase / Q8NHY2* / Q9R1A8*  / reaction
 ENSGALG00000005279 BRIP1 / Q3YK19 / Fanconi anemia group J protein homolog / Q5SXJ3* / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex
 ENSGALG00000003875 ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000016739 HERC2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / complex / reaction
 ENSGALG00000009901 DYRK2 / Q5ZIU3 / Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Q5U4C9* / Q92630*  / reaction
 ENSGALG00000004508 EYA2 / Gallus gallus EYA transcriptional coactivator and phosphatase 2 (EYA2), mRNA. / O00167* / O08575* / Eyes absent homolog 2 * / EYA transcriptional coactivator and phosphatase 2*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000040909 WRN / Werner syndrome RecQ like helicase / O09053* / Q14191*  / complex / reaction
 ENSGALG00000042491 P62801 / Histone H4   / complex
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / reaction / complex
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction






 

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