ENSGALG00000010748


Gallus gallus

Features
Gene ID: ENSGALG00000010748
  
Biological name :EXO1
  
Synonyms : EXO1 / exonuclease 1
  
Possible biological names infered from orthology : Q9QZ11 / Q9UQ84
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 35835014
Gene end: 35850100
  
Corresponding Affymetrix probe sets: GgaAffx.6785.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017465
NCBI entrez gene - 421505     See in Manteia.
RefSeq - XM_419550
swissprot - E1C1G7
Ensembl - ENSGALG00000010748
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exo1ENSDARG00000056832Danio rerio
 EXO1ENSG00000174371Homo sapiens
 Exo1ENSMUSG00000039748Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006084  XPG/Rad2 endonuclease
 IPR006085  XPG N-terminal
 IPR006086  XPG-I domain
 IPR008918  Helix-hairpin-helix motif, class 2
 IPR019974  XPG conserved site
 IPR020045  DNA polymerase I-like, H3TH domain
 IPR029060  PIN-like domain superfamily
 IPR032641  Exonuclease 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002455 humoral immune response mediated by circulating immunoglobulin IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IEA
 biological_processGO:0045190 isotype switching IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0035312 5"-3" exodeoxyribonuclease activity IEA
 molecular_functionGO:0045145 single-stranded DNA 5"-3" exodeoxyribonuclease activity IEA
 molecular_functionGO:0048256 flap endonuclease activity IEA
 molecular_functionGO:0051908 double-stranded DNA 5"-3" exodeoxyribonuclease activity IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex / reaction
 ENSGALG00000002663 ATR / ATR serine/threonine kinase / Q13535*  / reaction / complex
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / reaction / complex
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / reaction / complex
 ENSGALG00000008962 MSH2 / mutS homolog 2 / P43246* / P43247* / DNA mismatch repair protein Msh2 *  / reaction
 ENSGALG00000039169 MLH1 / mutL homolog 1 / P40692* / Q9JK91* / DNA mismatch repair protein Mlh1 *  / reaction
 ENSGALG00000008957 MSH6 / mutS homolog 6 / P52701* / P54276* / DNA mismatch repair protein Msh6 *  / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / reaction
 ENSGALG00000005279 BRIP1 / Q3YK19 / Fanconi anemia group J protein homolog / Q5SXJ3* / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / reaction / complex
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / reaction / complex






 

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