ENSGALG00000039169


Gallus gallus

Features
Gene ID: ENSGALG00000039169
  
Biological name :MLH1
  
Synonyms : MLH1 / mutL homolog 1
  
Possible biological names infered from orthology : DNA mismatch repair protein Mlh1 / P40692 / Q9JK91
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 46177380
Gene end: 46193446
  
Corresponding Affymetrix probe sets: Gga.10857.1.S1_s_at (Chicken Array)   GgaAffx.23773.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046377
NCBI entrez gene - 420729     See in Manteia.
RefSeq - XM_015281693
RefSeq - XM_418828
swissprot - A0A1D5P146
Ensembl - ENSGALG00000039169
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mlh1ENSDARG00000025948Danio rerio
 MLH1ENSG00000076242Homo sapiens
 Mlh1ENSMUSG00000032498Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002099  DNA mismatch repair protein family, N-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR013507  DNA mismatch repair protein, S5 domain 2-like
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR014762  DNA mismatch repair, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR032189  DNA mismatch repair protein Mlh1, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IEA
 biological_processGO:0000712 resolution of meiotic recombination intermediates IEA
 biological_processGO:0002204 somatic recombination of immunoglobulin genes involved in immune response IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007060 male meiosis chromosome segregation IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0007131 reciprocal meiotic recombination IEA
 biological_processGO:0007140 male meiotic nuclear division IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0016321 female meiosis chromosome segregation IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IEA
 biological_processGO:0016447 somatic recombination of immunoglobulin gene segments IEA
 biological_processGO:0043060 meiotic metaphase I plate congression IEA
 biological_processGO:0045132 meiotic chromosome segregation IEA
 biological_processGO:0045141 meiotic telomere clustering IEA
 biological_processGO:0045143 homologous chromosome segregation IEA
 biological_processGO:0045190 isotype switching IEA
 biological_processGO:0045950 negative regulation of mitotic recombination IEA
 biological_processGO:0048298 positive regulation of isotype switching to IgA isotypes IEA
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IEA
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0051257 meiotic spindle midzone assembly IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0001673 male germ cell nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005712 chiasma IEA
 cellular_componentGO:0005715 late recombination nodule IEA
 cellular_componentGO:0032300 mismatch repair complex IEA
 cellular_componentGO:0032389 MutLalpha complex IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0030983 mismatched DNA binding IEA
 molecular_functionGO:0032137 guanine/thymine mispair binding IEA
 molecular_functionGO:0032407 MutSalpha complex binding IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008962 MSH2 / mutS homolog 2 / P43246* / P43247* / DNA mismatch repair protein Msh2 *  / complex / reaction
 ENSGALG00000010748 EXO1 / exonuclease 1 / Q9QZ11* / Q9UQ84*  / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000008957 MSH6 / mutS homolog 6 / P52701* / P54276* / DNA mismatch repair protein Msh6 *  / complex / reaction






 

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