ENSMUSG00000032498


Mus musculus

Features
Gene ID: ENSMUSG00000032498
  
Biological name :Mlh1
  
Synonyms : DNA mismatch repair protein Mlh1 / Mlh1 / Q9JK91
  
Possible biological names infered from orthology : mutL homolog 1 / P40692
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 111228228
Gene end: 111271791
  
Corresponding Affymetrix probe sets: 10597288 (MoGene1.0st)   1417360_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142563
Ensembl peptide - ENSMUSP00000143786
Ensembl peptide - ENSMUSP00000035079
Ensembl peptide - ENSMUSP00000119170
NCBI entrez gene - 17350     See in Manteia.
MGI - MGI:101938
RefSeq - XM_006511948
RefSeq - XM_011242935
RefSeq - XM_006511951
RefSeq - NM_001324522
RefSeq - NM_026810
RefSeq Peptide - NP_001311451
RefSeq Peptide - NP_081086
swissprot - Q9JK91
swissprot - A0A0G2JH14
swissprot - A0A0G2JDY9
swissprot - F6R1G0
Ensembl - ENSMUSG00000032498
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mlh1ENSDARG00000025948Danio rerio
 MLH1ENSGALG00000039169Gallus gallus
 MLH1ENSG00000076242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002099  DNA mismatch repair protein family, N-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR011186  DNA mismatch repair protein Mlh1
 IPR013507  DNA mismatch repair protein, S5 domain 2-like
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR014762  DNA mismatch repair, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR032189  DNA mismatch repair protein Mlh1, C-terminal
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IMP
 biological_processGO:0000712 resolution of meiotic recombination intermediates IMP
 biological_processGO:0002204 somatic recombination of immunoglobulin genes involved in immune response IGI
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007060 male meiosis chromosome segregation IMP
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007131 reciprocal meiotic recombination IMP
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0016321 female meiosis chromosome segregation IMP
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IMP
 biological_processGO:0016447 somatic recombination of immunoglobulin gene segments IMP
 biological_processGO:0043060 meiotic metaphase I plate congression IMP
 biological_processGO:0045132 meiotic chromosome segregation IMP
 biological_processGO:0045141 meiotic telomere clustering IMP
 biological_processGO:0045143 homologous chromosome segregation IMP
 biological_processGO:0045190 isotype switching IMP
 biological_processGO:0045950 negative regulation of mitotic recombination IMP
 biological_processGO:0048298 positive regulation of isotype switching to IgA isotypes IMP
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IMP
 biological_processGO:0048477 oogenesis IMP
 biological_processGO:0051257 meiotic spindle midzone assembly IMP
 biological_processGO:0051321 meiotic cell cycle TAS
 cellular_componentGO:0000793 condensed chromosome IMP
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000795 synaptonemal complex ISS
 cellular_componentGO:0001673 male germ cell nucleus IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IDA
 cellular_componentGO:0005712 chiasma IDA
 cellular_componentGO:0005715 late recombination nodule IDA
 cellular_componentGO:0032300 mismatch repair complex IEA
 cellular_componentGO:0032389 MutLalpha complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IBA
 molecular_functionGO:0030983 mismatched DNA binding IEA
 molecular_functionGO:0032137 guanine/thymine mispair binding ISO
 molecular_functionGO:0032407 MutSalpha complex binding IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1b(EUCOMM)Hmgu/Mlh1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Mlh1tm1b(EUCOMM)Hmgu/H

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Mlh1tm1b(EUCOMM)Hmgu/Mlh1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Mlh1tm1b(EUCOMM)Hmgu/H

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Mlh1tm1b(EUCOMM)Hmgu/Mlh1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Mlh1tm1b(EUCOMM)Hmgu/H

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

Allelic Composition: Mgmttm1Mse/Mgmttm1Mse,Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Dnmt1tm1Pwl/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1tm1Pwl,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnmt1tm1Pwl/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnmt1tm1Pwl/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0003292 melena "dark colored, foul-smelling feces due to the presence of blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004208 basal cell carcinoma "a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd

 MP:0008966 abnormal chiasmata formation "atypical contact between nonsister chromatids of homologous chromosomes during meiosis I, precluding formation of the expected number of cross-shaped configurations representing recombination events" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0009222 uterus tumor "presence of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009309 small intestine adenocarcinoma "malignant neoplasm of epithelial cells in the small intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0009761 abnormal meiotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak,Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak,Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mlh1tm1Wed/Mlh1tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Dnmt1tm1Pwl/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1+,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dnmt1tm1Jae/Dnmt1tm1Pwl,Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Apctm1Rak/Apc+,Mlh1tm1Rak/Mlh1tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005370 Msh6 / P54276 / DNA mismatch repair protein Msh6 / P52701* / mutS homolog 6*  / complex / reaction
 ENSMUSG00000024151 Msh2 / P43247 / DNA mismatch repair protein Msh2 / P43246* / mutS homolog 2*  / reaction / complex
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction
 ENSMUSG00000079109 Pms2 / PMS1 homolog2, mismatch repair system component / P54278*  / complex / reaction






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr