ENSMUSG00000005370


Mus musculus

Features
Gene ID: ENSMUSG00000005370
  
Biological name :Msh6
  
Synonyms : DNA mismatch repair protein Msh6 / Msh6 / P54276
  
Possible biological names infered from orthology : mutS homolog 6 / P52701
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 87975050
Gene end: 87990883
  
Corresponding Affymetrix probe sets: 10447417 (MoGene1.0st)   1416915_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005503
NCBI entrez gene - 17688     See in Manteia.
MGI - MGI:1343961
RefSeq - NM_010830
RefSeq Peptide - NP_034960
swissprot - P54276
Ensembl - ENSMUSG00000005370
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msh6ENSDARG00000104541Danio rerio
 MSH6ENSGALG00000008957Gallus gallus
 MSH6ENSG00000116062Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR000432  DNA mismatch repair protein MutS, C-terminal
 IPR007695  DNA mismatch repair protein MutS-like, N-terminal
 IPR007696  DNA mismatch repair protein MutS, core
 IPR007860  DNA mismatch repair protein MutS, connector domain
 IPR007861  DNA mismatch repair protein MutS, clamp
 IPR015536  DNA mismatch repair protein MutS-homologue MSH6
 IPR016151  DNA mismatch repair protein MutS, N-terminal
 IPR017261  DNA mismatch repair protein MutS/MSH
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036187  DNA mismatch repair protein MutS, core domain superfamily
 IPR036678  MutS, connector domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006298 mismatch repair ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IMP
 biological_processGO:0016447 somatic recombination of immunoglobulin gene segments IMP
 biological_processGO:0043570 maintenance of DNA repeat elements IBA
 biological_processGO:0045190 isotype switching IMP
 biological_processGO:0045830 positive regulation of isotype switching IGI
 biological_processGO:0045910 negative regulation of DNA recombination IEA
 biological_processGO:0051096 positive regulation of helicase activity IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032301 MutSalpha complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0003677 DNA binding IMP
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003684 damaged DNA binding IMP
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008094 DNA-dependent ATPase activity IBA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0030983 mismatched DNA binding ISS
 molecular_functionGO:0032137 guanine/thymine mispair binding IEA
 molecular_functionGO:0032138 single base insertion or deletion binding IBA
 molecular_functionGO:0032142 single guanine insertion binding IEA
 molecular_functionGO:0032143 single thymine insertion binding IEA
 molecular_functionGO:0032357 oxidized purine DNA binding IEA
 molecular_functionGO:0032405 MutLalpha complex binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0043531 ADP binding IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh6tm1Wed/Msh6tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh6tm1Wed/Msh6tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Msh3tm1Htr/Msh3tm1Htr,Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msh6tm1Wed/Msh6tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mc4rM4Btlr/Mc4r+
Genetic Background: C57BL/6J-Mc4rM4Btlr

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004208 basal cell carcinoma "a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msh6tm1Wed/Msh6tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0009222 uterus tumor "presence of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009797 abnormal mismatch repair "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Msh3tm1Htr/Msh3tm1Htr,Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Msh3tm1Htr/Msh3tm1Htr,Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh6tm1Wed/Msh6tm1Wed
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh6tm1Wed/Msh6+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Msh3tm1Htr/Msh3tm1Htr,Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000079109 Pms2 / PMS1 homolog2, mismatch repair system component / P54278*  / reaction / complex
 ENSMUSG00000032498 Mlh1 / Q9JK91 / DNA mismatch repair protein Mlh1 / P40692* / mutL homolog 1*  / reaction / complex
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / reaction
 ENSMUSG00000024151 Msh2 / P43247 / DNA mismatch repair protein Msh2 / P43246* / mutS homolog 2*  / complex / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr