ENSMUSG00000024151


Mus musculus

Features
Gene ID: ENSMUSG00000024151
  
Biological name :Msh2
  
Synonyms : DNA mismatch repair protein Msh2 / Msh2 / P43247
  
Possible biological names infered from orthology : mutS homolog 2 / P43246
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 87672330
Gene end: 87723713
  
Corresponding Affymetrix probe sets: 10447395 (MoGene1.0st)   1416988_at (Mouse Genome 430 2.0 Array)   1447888_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024967
Ensembl peptide - ENSMUSP00000133488
Ensembl peptide - ENSMUSP00000133650
NCBI entrez gene - 17685     See in Manteia.
MGI - MGI:101816
RefSeq - NM_008628
RefSeq Peptide - NP_032654
swissprot - Q3TZI5
swissprot - G3UWZ8
swissprot - G3UXD8
swissprot - P43247
Ensembl - ENSMUSG00000024151
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msh2ENSDARG00000018022Danio rerio
 MSH2ENSGALG00000008962Gallus gallus
 MSH2ENSG00000095002Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000432  DNA mismatch repair protein MutS, C-terminal
 IPR007695  DNA mismatch repair protein MutS-like, N-terminal
 IPR007696  DNA mismatch repair protein MutS, core
 IPR007860  DNA mismatch repair protein MutS, connector domain
 IPR007861  DNA mismatch repair protein MutS, clamp
 IPR011184  DNA mismatch repair Msh2-type
 IPR016151  DNA mismatch repair protein MutS, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032642  DNA mismatch repair protein Msh2
 IPR036187  DNA mismatch repair protein MutS, core domain superfamily
 IPR036678  MutS, connector domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0002204 somatic recombination of immunoglobulin genes involved in immune response IGI
 biological_processGO:0006119 oxidative phosphorylation IMP
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006301 postreplication repair IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006311 meiotic gene conversion IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IMP
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0010165 response to X-ray IMP
 biological_processGO:0010224 response to UV-B IMP
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IMP
 biological_processGO:0016447 somatic recombination of immunoglobulin gene segments IMP
 biological_processGO:0019724 B cell mediated immunity IMP
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0031573 intra-S DNA damage checkpoint IGI
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043570 maintenance of DNA repeat elements IEA
 biological_processGO:0045128 negative regulation of reciprocal meiotic recombination IBA
 biological_processGO:0045190 isotype switching IMP
 biological_processGO:0045910 negative regulation of DNA recombination IEA
 biological_processGO:0048298 positive regulation of isotype switching to IgA isotypes IMP
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IMP
 biological_processGO:0051096 positive regulation of helicase activity IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0032300 mismatch repair complex IEA
 cellular_componentGO:0032301 MutSalpha complex ISO
 cellular_componentGO:0032302 MutSbeta complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0000403 Y-form DNA binding IBA
 molecular_functionGO:0000404 heteroduplex DNA loop binding IBA
 molecular_functionGO:0000406 double-strand/single-strand DNA junction binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IMP
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IBA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0019237 centromeric DNA binding IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030983 mismatched DNA binding IEA
 molecular_functionGO:0032137 guanine/thymine mispair binding IEA
 molecular_functionGO:0032138 single base insertion or deletion binding IBA
 molecular_functionGO:0032139 dinucleotide insertion or deletion binding IEA
 molecular_functionGO:0032142 single guanine insertion binding IEA
 molecular_functionGO:0032143 single thymine insertion binding IEA
 molecular_functionGO:0032181 dinucleotide repeat insertion binding IEA
 molecular_functionGO:0032357 oxidized purine DNA binding IEA
 molecular_functionGO:0032405 MutLalpha complex binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043531 ADP binding IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Msh2tm1Rak/Msh2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apctm1Rak/Apc+,Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0002050 pheochromocytoma "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Whl/Msh2tm1Whl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apctm1Rak/Apc+,Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: ApcMin/Apc+,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Msh2tm2.1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Msh2tm2.2Rak/Msh2tm2.2Rak
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1tm1Brd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Msh2tm2.1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Msh2tm2.1Rak/Msh2tm3.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Msh2tm1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Msh2tm2.1Rak/Msh2tm3.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Msh2tm1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Apctm1Rak/Apc+,Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Msh2tm1Rak/Msh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Msh2tm1Rak/Msh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Msh2tm2.1Rak/Msh2tm3.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Msh2tm1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Msh2tm1Htr/Msh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Msh2tm1Htr/Msh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004191 neuronal intranuclear inclusions "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator]
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Allelic Composition: Hrhr/Hrhr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: C57BL/6 * CBA

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004501 increased incidence of UV-induced tumors "higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Pcnatm1Jcbs/Pcnatm1Jcbs
Genetic Background: involves: 129P2/OlaHsd

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic Background: involves: 129 * C57BL/6

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2+,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Rak/Msh2tm1Rak,Xpctm1Ecf/Xpctm1Ecf
Genetic Background: involves: 129P2/OlaHsd * SKH1

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm2.1Rak/Msh2tm3.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Msh2tm1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0008884 abnormal enterocyte apoptosis "change in the timing or the number of enterocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0009222 uterus tumor "presence of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0009277 brain tumor "presence of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

 MP:0009309 small intestine adenocarcinoma "malignant neoplasm of epithelial cells in the small intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm2.1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

 MP:0009320 lymphoblastic lymphoma "diffuse lymphoma with supradiaphragmatic distribution and T lymphocytes having convoluted nuclei" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009797 abnormal mismatch repair "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298]
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Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Msh2tm2.1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Msh2tm2.1Rak/Msh2tm3.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Msh2tm1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

Allelic Composition: Msh2tm2.2Rak/Msh2tm2.2Rak
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: ApcMin/Apc+,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

Allelic Composition: Msh2tm2.1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Msh2tm2.1Rak/Msh2tm3.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Msh2tm1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

Allelic Composition: Msh2tm2.2Rak/Msh2tm2.2Rak
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Htr/Msh2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Tap1tm1Hpl/Tap1tm1Hpl
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010345 increased thyroid C-cell carcinoma incidence "greater than the expected number of a malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland, occurring in a specific population in a given time period" [MPATH:308]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0010350 increased pituitary adenohypophysis tumor incidence "greater than the expected number of neoplasms in the anterior part of the pituitary that secretes a variety of hormones, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0010351 increased pituitary melanotroph tumor incidence "greater than the expected number of neoplasms derived from the cells of intermediate pituitary that produce melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC)" [CL:0000440, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msh2tm1Whl/Msh2tm1Whl,Rb1tm1Brd/Rb1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mlh1tm1Rak/Mlh1tm1Rak,Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

Allelic Composition: Msh2tm1Rak/Msh2tm1Rak,Pold1tm1.1Bdp/Pold1tm1.1Bdp
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh2tm1Mtn/Msh2tm1Mtn
Genetic Background: involves: C57BL/6

Allelic Composition: Msh2tm1Wed/Msh2tm1Wed
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Rak/Msh2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Rak/Msh2tm1Rak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hrhr/Hrhr,Msh2tm1Htr/Msh2tm1Htr,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Msh2tm2.1Rak/Msh2tm2.1Rak,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Msh2tm2.2Rak/Msh2tm2.2Rak
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005370 Msh6 / P54276 / DNA mismatch repair protein Msh6 / P52701* / mutS homolog 6*  / complex / reaction
 ENSMUSG00000032498 Mlh1 / Q9JK91 / DNA mismatch repair protein Mlh1 / P40692* / mutL homolog 1*  / complex / reaction
 ENSMUSG00000079109 Pms2 / PMS1 homolog2, mismatch repair system component / P54278*  / complex / reaction
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / reaction
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / complex / reaction






 

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