ENSDARG00000018022


Danio rerio

Features
Gene ID: ENSDARG00000018022
  
Biological name :msh2
  
Synonyms : msh2 / mutS homolog 2 (E. coli)
  
Possible biological names infered from orthology : DNA mismatch repair protein Msh2 / mutS homolog 2 / P43246 / P43247
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 24906106
Gene end: 24928497
  
Corresponding Affymetrix probe sets: Dr.2637.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000027768
NCBI entrez gene - 406845     See in Manteia.
RefSeq - NM_213524
RefSeq Peptide - NP_998689
swissprot - F1QEP5
ZFIN ID - ZDB-GENE-040426-2932
Ensembl - ENSDARG00000018022
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MSH2ENSGALG00000008962Gallus gallus
 MSH2ENSG00000095002Homo sapiens
 Msh2ENSMUSG00000024151Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000432  DNA mismatch repair protein MutS, C-terminal
 IPR007695  DNA mismatch repair protein MutS-like, N-terminal
 IPR007696  DNA mismatch repair protein MutS, core
 IPR007860  DNA mismatch repair protein MutS, connector domain
 IPR007861  DNA mismatch repair protein MutS, clamp
 IPR011184  DNA mismatch repair Msh2-type
 IPR016151  DNA mismatch repair protein MutS, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032642  DNA mismatch repair protein Msh2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006298 mismatch repair ISS
 biological_processGO:0006301 postreplication repair IBA
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0006311 meiotic gene conversion IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010165 response to X-ray IBA
 biological_processGO:0010224 response to UV-B IBA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IBA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
 biological_processGO:0043570 maintenance of DNA repeat elements IMP
 biological_processGO:0045128 negative regulation of reciprocal meiotic recombination IBA
 biological_processGO:0045190 isotype switching IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0032300 mismatch repair complex IEA
 cellular_componentGO:0032301 MutSalpha complex IEA
 cellular_componentGO:0032302 MutSbeta complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IBA
 molecular_functionGO:0000403 Y-form DNA binding IBA
 molecular_functionGO:0000404 heteroduplex DNA loop binding IBA
 molecular_functionGO:0000406 double-strand/single-strand DNA junction binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IBA
 molecular_functionGO:0030983 mismatched DNA binding IEA
 molecular_functionGO:0032137 guanine/thymine mispair binding IGI
 molecular_functionGO:0032138 single base insertion or deletion binding IBA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism neoplastic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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