ENSGALG00000008962


Gallus gallus

Features
Gene ID: ENSGALG00000008962
  
Biological name :MSH2
  
Synonyms : MSH2 / mutS homolog 2
  
Possible biological names infered from orthology : DNA mismatch repair protein Msh2 / P43246 / P43247
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 8658316
Gene end: 8685996
  
Corresponding Affymetrix probe sets: Gga.9265.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014557
NCBI entrez gene - 378799     See in Manteia.
RefSeq - XM_015278122
swissprot - F1NV33
Ensembl - ENSGALG00000008962
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msh2ENSDARG00000018022Danio rerio
 MSH2ENSG00000095002Homo sapiens
 Msh2ENSMUSG00000024151Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000432  DNA mismatch repair protein MutS, C-terminal
 IPR007695  DNA mismatch repair protein MutS-like, N-terminal
 IPR007696  DNA mismatch repair protein MutS, core
 IPR007860  DNA mismatch repair protein MutS, connector domain
 IPR007861  DNA mismatch repair protein MutS, clamp
 IPR011184  DNA mismatch repair Msh2-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032642  DNA mismatch repair protein Msh2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0002204 somatic recombination of immunoglobulin genes involved in immune response IEA
 biological_processGO:0006119 oxidative phosphorylation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006298 mismatch repair IBA
 biological_processGO:0006301 postreplication repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006311 meiotic gene conversion IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0008340 determination of adult lifespan IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0010224 response to UV-B IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IEA
 biological_processGO:0016447 somatic recombination of immunoglobulin gene segments IEA
 biological_processGO:0019724 B cell mediated immunity IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0031573 intra-S DNA damage checkpoint IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043570 maintenance of DNA repeat elements IEA
 biological_processGO:0045128 negative regulation of reciprocal meiotic recombination IBA
 biological_processGO:0045190 isotype switching IEA
 biological_processGO:0045910 negative regulation of DNA recombination IEA
 biological_processGO:0048298 positive regulation of isotype switching to IgA isotypes IEA
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IEA
 biological_processGO:0051096 positive regulation of helicase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0032300 mismatch repair complex IEA
 cellular_componentGO:0032301 MutSalpha complex IEA
 cellular_componentGO:0032302 MutSbeta complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0000403 Y-form DNA binding IBA
 molecular_functionGO:0000404 heteroduplex DNA loop binding IBA
 molecular_functionGO:0000406 double-strand/single-strand DNA junction binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IBA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0019237 centromeric DNA binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030983 mismatched DNA binding IEA
 molecular_functionGO:0032137 guanine/thymine mispair binding IEA
 molecular_functionGO:0032138 single base insertion or deletion binding IBA
 molecular_functionGO:0032139 dinucleotide insertion or deletion binding IEA
 molecular_functionGO:0032142 single guanine insertion binding IEA
 molecular_functionGO:0032143 single thymine insertion binding IEA
 molecular_functionGO:0032181 dinucleotide repeat insertion binding IEA
 molecular_functionGO:0032357 oxidized purine DNA binding IEA
 molecular_functionGO:0032405 MutLalpha complex binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043531 ADP binding IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000039169 MLH1 / mutL homolog 1 / P40692* / Q9JK91* / DNA mismatch repair protein Mlh1 *  / complex / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000010748 EXO1 / exonuclease 1 / Q9QZ11* / Q9UQ84*  / reaction
 ENSGALG00000008957 MSH6 / mutS homolog 6 / P52701* / P54276* / DNA mismatch repair protein Msh6 *  / complex / reaction






 

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