ENSDARG00000025948


Danio rerio

Features
Gene ID: ENSDARG00000025948
  
Biological name :mlh1
  
Synonyms : mlh1 / mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
  
Possible biological names infered from orthology : DNA mismatch repair protein Mlh1 / mutL homolog 1 / P40692 / Q9JK91
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 42602406
Gene end: 42617639
  
Corresponding Affymetrix probe sets: Dr.13195.1.A1_at (Zebrafish Array)   NM_200659_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000113460
Ensembl peptide - ENSDARP00000121589
NCBI entrez gene - 393632     See in Manteia.
RefSeq - NM_200659
RefSeq Peptide - NP_956953
swissprot - B8A6F5
swissprot - B8A6F4
ZFIN ID - ZDB-GENE-040426-1600
Ensembl - ENSDARG00000025948
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MLH1ENSGALG00000039169Gallus gallus
 MLH1ENSG00000076242Homo sapiens
 Mlh1ENSMUSG00000032498Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002099  DNA mismatch repair protein family, N-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR013507  DNA mismatch repair protein, S5 domain 2-like
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR014762  DNA mismatch repair, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR032189  DNA mismatch repair protein Mlh1, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006298 mismatch repair IBA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IBA
 biological_processGO:0043060 meiotic metaphase I plate congression IMP
 biological_processGO:0051026 chiasma assembly IMP
 cellular_componentGO:0000795 synaptonemal complex IBA
 cellular_componentGO:0005712 chiasma IBA
 cellular_componentGO:0032300 mismatch repair complex IEA
 cellular_componentGO:0032389 MutLalpha complex IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IBA
 molecular_functionGO:0030983 mismatched DNA binding IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000242 male organism male organism male sterile , abnormal
male organism decreased male fertility , abnormal
male organism triploid , abnormal
Show

 ZFA:0000303 female organism female organism lethal (sensu genetics) , abnormal
female organism aneuploid , abnormal
Show

 ZFA:0000598 testis testis increased weight , abnormal
testis apoptotic , abnormal
Show

 ZFA:0001094 whole organism whole organism neoplastic , abnormal
whole organism increased size , abnormal
whole organism apoptotic , abnormal
whole organism necrotic , abnormal
whole organism brood viability , abnormal
whole organism aneuploid , abnormal
whole organism deformed , abnormal
Show

 ZFA:0009005 spermatocyte spermatocyte decreased amount , abnormal
spermatocyte recombination nodule absent , abnormal
spermatocyte increased amount , abnormal
Show

 ZFA:0009006 sperm sperm absent , abnormal
sperm decreased amount , abnormal
Show

 ZFA:0009007 spermatogonium spermatogonium increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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