ENSGALG00000002663


Gallus gallus

Features
Gene ID: ENSGALG00000002663
  
Biological name :ATR
  
Synonyms : ATR / ATR serine/threonine kinase
  
Possible biological names infered from orthology : Q13535
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 10472558
Gene end: 10508150
  
Corresponding Affymetrix probe sets: GgaAffx.1740.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004185
Ensembl peptide - ENSGALP00000047688
NCBI entrez gene - 424777     See in Manteia.
RefSeq - XM_015276960
swissprot - A0A1D5P4S6
swissprot - F1NGW1
Ensembl - ENSGALG00000002663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atrENSDARG00000079625Danio rerio
 ATRENSG00000175054Homo sapiens
 AtrENSMUSG00000032409Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKDC / DNA-dependent protein kinase catalytic subunit / P78527* / P97313* / protein kinase, DNA-activated, catalytic polypeptide*ENSGALG0000004246917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR012993  UME domain
 IPR014009  PIK-related kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR021133  HEAT, type 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0070198 protein localization to chromosome, telomeric region IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0090399 replicative senescence IEA
 biological_processGO:0097694 establishment of RNA localization to telomere IEA
 biological_processGO:1904884 positive regulation of telomerase catalytic core complex assembly IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0032405 MutLalpha complex binding IEA
 molecular_functionGO:0032407 MutSalpha complex binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000102 UBE2T / ubiquitin conjugating enzyme E2 T / Q9CQ37* / Q9NPD8*  / complex / reaction
 ENSGALG00000006051 CDC7 / cell division cycle 7 / O00311* / Q9Z0H0* / Cell division cycle 7-related protein kinase *  / reaction
 ENSGALG00000010748 EXO1 / exonuclease 1 / Q9QZ11* / Q9UQ84*  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / reaction / complex
 ENSGALG00000014982 RBBP8 / RB binding protein 8, endonuclease / Q80YR6* / Q99708* / retinoblastoma binding protein 8, endonuclease*  / reaction / complex
 ENSGALG00000005028 TOP3A / DNA topoisomerase 3-alpha isoform 1 / O70157* / Q13472* / DNA topoisomerase III alpha* / topoisomerase (DNA) III alpha*  / complex / reaction
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / reaction / complex
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / reaction / complex
 ENSGALG00000042418 CHEK1 / Q8AYC9 / Serine/threonine-protein kinase Chk1 / O14757* / O35280* / checkpoint kinase 1*  / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000004037 DNA2 / Q5ZKG3 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / Q6ZQJ5* / DNA replication helicase...  / complex / reaction
 ENSGALG00000007155 RMI2 / Q5ZM20 / RecQ-mediated genome instability protein 2 / Q96E14* / Q3UPE3* / RecQ mediated genome instability 2*  / reaction / complex
 ENSGALG00000034198 MCM10 / minichromosome maintenance 10 replication initiation factor / Q0VBD2* / Q7L590*  / reaction
 ENSGALG00000040909 WRN / Werner syndrome RecQ like helicase / O09053* / Q14191*  / complex / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000005279 BRIP1 / Q3YK19 / Fanconi anemia group J protein homolog / Q5SXJ3* / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction
 ENSGALG00000003720 FANCD2 / Fanconi anemia complementation group D2 / Q80V62* / Q9BXW9* / Fanconi anemia group D2 protein homolog *  / complex / reaction






 

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