ENSDARG00000079625


Danio rerio

Features
Gene ID: ENSDARG00000079625
  
Biological name :atr
  
Synonyms : atr / ATR serine/threonine kinase
  
Possible biological names infered from orthology : Q13535
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 16384285
Gene end: 16449504
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000118304
NCBI entrez gene - 567770     See in Manteia.
RefSeq - XM_691071
swissprot - F1QMM7
ZFIN ID - ZDB-GENE-070912-458
Ensembl - ENSDARG00000079625
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATRENSGALG00000002663Gallus gallus
 ATRENSG00000175054Homo sapiens
 AtrENSMUSG00000032409Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkdc / protein kinase, DNA-activated, catalytic polypeptide / P78527* / P97313* / DNA-dependent protein kinase catalytic subunit *ENSDARG0000007508317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR012993  UME domain
 IPR014009  PIK-related kinase
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035469 determination of pancreatic left/right asymmetry IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:1901207 regulation of heart looping IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased size , abnormal
Kupffers vesicle motile cilium decreased length , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm mislocalised , abnormal
lateral plate mesoderm right side mislocalised , abnormal
Show

 ZFA:0000140 pancreas pancreas mislocalised , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism anterior-posterior axis increased curvature , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr