ENSDARG00000075083


Danio rerio

Features
Gene ID: ENSDARG00000075083
  
Biological name :prkdc
  
Synonyms : prkdc / protein kinase, DNA-activated, catalytic polypeptide
  
Possible biological names infered from orthology : DNA-dependent protein kinase catalytic subunit / P78527 / P97313
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 41348543
Gene end: 41396860
  
Corresponding Affymetrix probe sets: Dr.939.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000051678
NCBI entrez gene - 562283     See in Manteia.
RefSeq - XM_009303401
swissprot - E7F4J7
ZFIN ID - ZDB-GENE-030131-9008
Ensembl - ENSDARG00000075083
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKDCENSGALG00000042469Gallus gallus
 PRKDCENSG00000253729Homo sapiens
 PrkdcENSMUSG00000022672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
atr / ATR serine/threonine kinase / Q13535*ENSDARG0000007962511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR012582  NUC194
 IPR014009  PIK-related kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0033152 immunoglobulin V(D)J recombination IMP
 biological_processGO:0033153 T cell receptor V(D)J recombination IMP
 biological_processGO:0071707 immunoglobulin heavy chain V-D-J recombination IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004677 DNA-dependent protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IBA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000436 spleen spleen absent , abnormal
spleen decreased size , abnormal
Show

 ZFA:0000529 kidney kidney absent , abnormal
kidney decreased thickness , abnormal
kidney decreased mass density , abnormal
Show

 ZFA:0001078 thymus thymus decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism neoplastic , abnormal
whole organism neoplasm increased amount , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0009250 lymphocyte lymphocyte decreased amount , abnormal
Show

 ZFA:0009265 monocyte monocyte increased amount , abnormal
Show

 ZFA:0009327 neutrophil neutrophil increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000020600 Q5RFV4 / rnf144aa / ring finger protein 144aa / Q925F3* / P50876* / RNF144A* / ring finger protein 144A* / E3 ubiquitin-protein ligase RNF144A *  / complex / reaction
 ENSDARG00000075083 prkdc / protein kinase, DNA-activated, catalytic polypeptide / P78527* / P97313* / DNA-dependent protein kinase catalytic subunit *  / complex / reaction
 ENSDARG00000045704 Q5RGE5 / dclre1c / DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) / Q96SD1* / Q8K4J0* / Protein artemis * / DNA cross-link repair 1C*  / complex / reaction
 ENSDARG00000042557 rnf144ab / ring finger protein 144ab / P50876* / Q925F3* / RNF144A* / ring finger protein 144A* / E3 ubiquitin-protein ligase RNF144A *  / reaction / complex
 ENSDARG00000060620 lig4 / ligase IV, DNA, ATP-dependent / P49917* / Q8BTF7* / DNA ligase 4*  / reaction
 ENSDARG00000010732 xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / reaction
 ENSDARG00000071551 xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / complex / reaction
 ENSDARG00000099298 xrcc5 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction / complex






 

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