ENSMUSG00000022672


Mus musculus

Features
Gene ID: ENSMUSG00000022672
  
Biological name :Prkdc
  
Synonyms : DNA-dependent protein kinase catalytic subunit / P97313 / Prkdc
  
Possible biological names infered from orthology : P78527 / protein kinase, DNA-activated, catalytic polypeptide
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A2
Gene start: 15637866
Gene end: 15842235
  
Corresponding Affymetrix probe sets: 10433797 (MoGene1.0st)   1451576_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023352
NCBI entrez gene - 19090     See in Manteia.
MGI - MGI:104779
RefSeq - XM_017316892
RefSeq - NM_011159
RefSeq - XM_006521861
RefSeq Peptide - NP_035289
swissprot - P97313
Ensembl - ENSMUSG00000022672
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkdcENSDARG00000075083Danio rerio
 PRKDCENSGALG00000042469Gallus gallus
 PRKDCENSG00000253729Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atr / ATR serine/threonine kinase / Q13535*ENSMUSG0000003240911


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR012582  NUC194
 IPR014009  PIK-related kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IMP
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002326 B cell lineage commitment IMP
 biological_processGO:0002328 pro-B cell differentiation IMP
 biological_processGO:0002360 T cell lineage commitment IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002377 immunoglobulin production IEA
 biological_processGO:0002638 negative regulation of immunoglobulin production IEA
 biological_processGO:0002684 positive regulation of immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007420 brain development IGI
 biological_processGO:0007507 heart development IGI
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016233 telomere capping IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030098 lymphocyte differentiation IMP
 biological_processGO:0031648 protein destabilization IDA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0033151 V(D)J recombination IGI
 biological_processGO:0033152 immunoglobulin V(D)J recombination IMP
 biological_processGO:0033153 T cell receptor V(D)J recombination IMP
 biological_processGO:0035234 ectopic germ cell programmed cell death IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048639 positive regulation of developmental growth IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 biological_processGO:2001229 negative regulation of response to gamma radiation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0070419 nonhomologous end joining complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004677 DNA-dependent protein kinase activity ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Prkdcm4Btlr/Prkdcm4Btlr
Genetic Background: C57BL/6J-Prkdcm4Btlr

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Muc2keny/Muc2keny
Genetic Background: C57BL/6JAnu-Muc2keny/Apb

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0000346 broad head "a greater ear- to -ear distance resulting in the appearance of a wide face and a flattened snout" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Prkdctm1Get/Prkdctm1Get,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmx1adr-11J/Lmx1adr-11J
Genetic Background: involves: C57BL/6J * CB17 * NOD

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000618 small salivary gland "reduced size of the saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Glra1spd/Glra1spd
Genetic Background: B6C3Fe a/a-Glra1spd/J

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasa3scat/Rasa3scat
Genetic Background: involves: BALB/cBy

 MP:0000687 small lymphoid organs "reduced size of lymphatic tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: PrkdcTg(INS-PDE2)5-1Lmb/?
Genetic Background: involves: FVB/N

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000726 absent lymphocyte "lack of specific white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Prkdctm1.1Bpcc/Prkdc+
Genetic Background: involves: 129 * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-HBEGF*L148S*P149T)70Rin/0
Genetic Background: CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: PrkdcTg(INS-PDE2)5-1Lmb/?
Genetic Background: involves: FVB/N

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm8.1Nerl/Cebpa+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: B6.129-Nos1tm1(cre)Mgmj

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcm7Btlr/Prkdcm7Btlr
Genetic Background: C57BL/6J-Prkdcm7Btlr

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcm1Btlr/Prkdcm1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Prkdcm2Btlr/Prkdcm2Btlr
Genetic Background: C57BL/6J-Prkdcm2Btlr

Allelic Composition: Prkdcm3Btlr/Prkdcm3Btlr
Genetic Background: C57BL/6J-Prkdcm3Btlr

Allelic Composition: Prkdcm7Btlr/Prkdcm7Btlr
Genetic Background: C57BL/6J-Prkdcm7Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Prkdcm1Btlr/Prkdcm1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Prkdcm2Btlr/Prkdcm2Btlr
Genetic Background: C57BL/6J-Prkdcm2Btlr

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Muc2keny/Muc2keny
Genetic Background: C57BL/6JAnu-Muc2keny/Apb

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Muc2keny/Muc2keny
Genetic Background: C57BL/6JAnu-Muc2keny/Apb

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: PrkdcTg(INS-PDE2)5-1Lmb/?
Genetic Background: involves: FVB/N

Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0002009 preneoplasia "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Emv30b/Emv30b,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Emv30b Prkdcscid/Dvs

Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Glra1spd/Glra1spd
Genetic Background: B6C3Fe a/a-Glra1spd/J

Allelic Composition: Prkdcscid/Prkdcscid,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Mom/Rag1+,Tg(LPV-TAg1135)11Tvd/0,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Prkdcscid/Prkdc+,Tg(LPV-TAg1135)11Tvd/0
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Prkdcscid/Prkdcscid,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Prkdcdxnph/Prkdcdxnph
Genetic Background: 129X1/SvJ

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr2tm1Arca/Gabbr2tm1Arca
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0002367 abnormal thymus lobule morphology "anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasa3scat/Rasa3scat
Genetic Background: involves: BALB/cBy

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Dnmt1tm1Jae/Dnmt1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(Tcrb)93Vbo/0
Genetic Background: involves: C57BL/Lia * CB17 * CBA/BrA

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Tg(CAG-PGDS)S-55Hjl/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ercc1tm1Dwm/Ercc1tm1Dwm,Tg(Ttr-Ercc1)17Dwm/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Prkdcscid/Prkdcscid,Tg(Tcrb)93Vbo/0
Genetic Background: involves: C57BL/Lia * CB17 * CBA/BrA

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msx2m1Btlr/Msx2m1Btlr
Genetic Background: C57BL/6J-Msx2m1Btlr

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0002473 impaired complement classical pathway "abnormal function of the plasma protein cascade triggered by antigen:antibody complexes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PrkdcM10Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM10Btlr

Allelic Composition: PrkdcM11Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM11Btlr

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dock2m2Anu/Dock2m2Anu
Genetic Background: C57BL/6JAnu-Dock2m2Anu

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-HBEGF*L148S*P149T)70Rin/0
Genetic Background: CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Glra1spd/Glra1spd
Genetic Background: B6C3Fe a/a-Glra1spd/J

Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002782 abnormal testicular secretion "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkdchanky/Prkdchanky
Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0002879 increased sensitivity to X-ray irradiation "increased incidence of cell death following high levels of X-ray irradiation" [RGD:Rat Genome Database submission]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Prkdcdxnph/Prkdcdxnph
Genetic Background: 129X1/SvJ

Allelic Composition: Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-HBEGF*L148S*P149T)70Rin/0
Genetic Background: CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Glra1spd/Glra1spd
Genetic Background: B6C3Fe a/a-Glra1spd/J

 MP:0003642 absent seminal gland "absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Glra1spd/Glra1spd
Genetic Background: B6C3Fe a/a-Glra1spd/J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Glra1spd/Glra1spd
Genetic Background: B6C3Fe a/a-Glra1spd/J

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: T/tAE5
Genetic Background: Not Specified

 MP:0004503 decreased incidence of ionizing radiation-induced tumors "lower than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ercc1tm1Dwm/Ercc1tm1Dwm,Tg(Ttr-Ercc1)17Dwm/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar

Allelic Composition: Prkdcscid/Prkdcscid,Tg(Ins2-Fasl)24Ach/0
Genetic Background: NOD.CB17-Prkdcscid Tg(Ins2-Fasl)24Ach

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(Ins2-Fasl)24Ach/0
Genetic Background: NOD.CB17-Prkdcscid Tg(Ins2-Fasl)24Ach

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Prkdcm1Btlr/Prkdcm1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(Tcrb)93Vbo/0
Genetic Background: involves: C57BL/Lia * CB17 * CBA/BrA

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cav3tm1Ncnp/Cav3+,Dmdmdx/Dmdmdx
Genetic Background: involves: 129S4/SvJae * C57BL/10 * C57BL/10ScSn

Allelic Composition: PrkdcM9Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM9Btlr

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Prkdchanky/Prkdchanky
Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Prkdcm1Btlr/Prkdcm1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

Allelic Composition: Prkdcm2Btlr/Prkdcm2Btlr
Genetic Background: C57BL/6J-Prkdcm2Btlr

Allelic Composition: Prkdcm4Btlr/Prkdcm4Btlr
Genetic Background: C57BL/6J-Prkdcm4Btlr

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdchanky/Prkdchanky
Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-HBEGF*L148S*P149T)70Rin/0
Genetic Background: CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Prkdcdxnph/Prkdcdxnph
Genetic Background: 129X1/SvJ

Allelic Composition: Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

Allelic Composition: Dxmod/Dxmod,Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Glra1spd/Glra1spd
Genetic Background: B6C3Fe a/a-Glra1spd/J

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: a/a,Oca2p/Oca2p
Genetic Background: Not Specified

Allelic Composition: Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/0,Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid Tg(B2M)55Hpl/Sz

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy

Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: NOD.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid/J

Allelic Composition: Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/0,Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid Tg(B2M)55Hpl/Sz

 MP:0005673 decreased susceptibility to graft versus host disease "less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: NOD.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

 MP:0006198 enophthalmos "sinking or retraction of the eye back into the socket" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm8.1Nerl/Cebpa+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Prkdcberty/Prkdcberty
Genetic Background: C57BL/6JAnu-Prkdcberty

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcberty/Prkdcberty
Genetic Background: C57BL/6JAnu-Prkdcberty

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcm4Btlr/Prkdcm4Btlr
Genetic Background: C57BL/6J-Prkdcm4Btlr

Allelic Composition: Prkdcm6Btlr/Prkdcm6Btlr
Genetic Background: C57BL/6J-Prkdcm6Btlr

Allelic Composition: PrkdcM8Btlr/PrkdcM8Btlr
Genetic Background: C57BL/6J-PrkdcM8Btlr

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Prkdcm2Btlr/Prkdcm2Btlr
Genetic Background: C57BL/6J-Prkdcm2Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcm6Btlr/Prkdcm6Btlr
Genetic Background: C57BL/6J-Prkdcm6Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Prkdcm2Btlr/Prkdcm2Btlr
Genetic Background: C57BL/6J-Prkdcm2Btlr

Allelic Composition: PrkdcM8Btlr/PrkdcM8Btlr
Genetic Background: C57BL/6J-PrkdcM8Btlr

Allelic Composition: PrkdcM8Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM8Btlr

Allelic Composition: PrkdcM10Btlr/PrkdcM10Btlr
Genetic Background: C57BL/6J-PrkdcM10Btlr

Allelic Composition: PrkdcM10Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM10Btlr

 MP:0008081 abnormal single-positive T cell number "anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(Tcrb)93Vbo/0
Genetic Background: involves: C57BL/Lia * CB17 * CBA/BrA

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdchanky/Prkdchanky
Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdchanky/Prkdchanky
Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Cav3tm1Ncnp/Cav3+,Dmdmdx/Dmdmdx
Genetic Background: involves: 129S4/SvJae * C57BL/10 * C57BL/10ScSn

Allelic Composition: PrkdcM9Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM9Btlr

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Prkdcm4Btlr/Prkdcm4Btlr
Genetic Background: C57BL/6J-Prkdcm4Btlr

Allelic Composition: PrkdcM9Btlr/PrkdcM9Btlr
Genetic Background: C57BL/6J-PrkdcM9Btlr

Allelic Composition: PrkdcM9Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM9Btlr

 MP:0008195 abnormal antigen presenting cell morphology "any structural anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response" [CL:0000145, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm8.1Nerl/Cebpa+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0008402 increased cellular sensitivity to alkylating agents "greater incidence of cell death following exposure to agents that cause DNA damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prkdchanky/Prkdchanky
Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: PrkdcM8Btlr/PrkdcM8Btlr
Genetic Background: C57BL/6J-PrkdcM8Btlr

 MP:0008754 abnormal T cell receptor V(D)J recombination "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0008755 abnormal immunoglobulin V(D)J recombination "any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033152, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0008756 abnormal T cell receptor alpha chain V-J recombination "any anomaly in the process by which V and J gene segments of the T cell receptor alpha chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008759 abnormal T cell receptor delta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor delta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008761 abnormal immunoglobulin light chain V-J recombination "any anomaly in the process by which V and J gene segments of the immunoglobulin light chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0008800 increased small intestinal crypt cell apoptosis "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

Allelic Composition: Il2rgtm1Wjl/Y,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0008838 decreased transforming growth factor level "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Prkdcdxnph/Prkdcdxnph
Genetic Background: 129X1/SvJ

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0009332 abnormal splenocyte morphology "any structural anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdchanky/Prkdchanky
Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdctm1Get/Prkdctm1Get
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0009697 abnormal copulation "an anomaly in sexual union that normally enables the transfer of ejaculate (sperm) from male to female, sometimes resulting in the fertilization of an egg" [GO:0007620, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0009856 failure of ejaculation "inability to propulse semen from the genital ducts and the urethra to the exterior within a defined test period" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0010250 absent thymus cortex "lacking the outer part of the thymus lobule which surrounds the medulla and is normally composed of closely packed lymphocytes" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdchanky/Prkdchanky
Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/6 * CB17

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Prkdcm7Btlr/Prkdcm7Btlr
Genetic Background: C57BL/6J-Prkdcm7Btlr

 MP:0010845 decreased effector memory CD4-positive, alpha-beta T cell number "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: PrkdcM9Btlr/PrkdcM9Btlr
Genetic Background: C57BL/6J-PrkdcM9Btlr

Allelic Composition: PrkdcM9Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM9Btlr

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Prkdctm1.1Bpcc/Prkdctm1.1Bpcc
Genetic Background: involves: 129 * C57BL/6

 MP:0011473 increased urine glycosaminoglycan level "greater in the amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [MGI:csmith]
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Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Dmdmdx/Dmdmdx,Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0012764 increased alpha-beta T cell number "greater number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: Prkdcm4Btlr/Prkdcm4Btlr
Genetic Background: C57BL/6J-Prkdcm4Btlr

Allelic Composition: Prkdcm6Btlr/Prkdcm6Btlr
Genetic Background: C57BL/6J-Prkdcm6Btlr

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Prkdcm6Btlr/Prkdcm6Btlr
Genetic Background: C57BL/6J-Prkdcm6Btlr

 MP:0013741 absent thymus corticomedullary boundary " complete absence or loss of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; normally, this is the site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:Anna, PMID:17067941]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0014127 increased thymoma incidence "greater than the expected number of a malignant neoplasm originating from the epithelial cells of the thymus, occurring in a specific population in a given time period; thymoma is an uncommon tumor linked with myasthenia gravis and other autoimmune diseases" [http://medical-dictionary.thefreedictionary.com/thymoma, http://www.cancer.gov/cancertopics/pdq/treatment/thymoma/patient/page1#_139]
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Allelic Composition: Rag1tm1Mom/Rag1+,Tg(LPV-TAg1135)11Tvd/0,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Prkdcscid/Prkdc+,Tg(LPV-TAg1135)11Tvd/0
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Prkdcscid/Prkdc+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0014130 thymus cysts "presence of fluid-filled spaces lined by epithelium within the thymus; thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (Hassall) corpuscles and epithelial reticulum of the thymus; congenital cysts are unilocular, whereas acquired cysts are usually multilocular and result as a consequence of inflammatory processes" [http://www.pedsradiology.com/historyanswer.aspx?qid=408&fid=1, PMID:23050117]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: B6.CB17-Prkdcscid/Sz

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Prkdcm3Btlr/Prkdcm3Btlr
Genetic Background: C57BL/6J-Prkdcm3Btlr

 MP:0020155 enhanced humoral immune response "enhanced response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: PrkdcM10Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM10Btlr

Allelic Composition: PrkdcM11Btlr/Prkdc+
Genetic Background: C57BL/6J-PrkdcM11Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020474 Polm / Q9JIW4 / polymerase (DNA directed), mu / Q9NP87* / DNA polymerase mu*  / reaction
 ENSMUSG00000020642 Q925F3 / Rnf144a / E3 ubiquitin-protein ligase RNF144A / P50876* / ring finger protein 144A*  / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / complex / reaction
 ENSMUSG00000022672 Prkdc / P97313 / DNA-dependent protein kinase catalytic subunit / P78527* / protein kinase, DNA-activated, catalytic polypeptide*  / reaction / complex
 ENSMUSG00000021615 Xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / reaction
 ENSMUSG00000025218 Poll / Q9QXE2 / polymerase (DNA directed), lambda / Q9UGP5* / DNA polymerase lambda*  / reaction
 ENSMUSG00000026187 Xrcc5 / P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction / complex
 ENSMUSG00000022471 Xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / complex / reaction
 ENSMUSG00000049717 Lig4 / Q8BTF7 / ligase IV, DNA, ATP-dependent / P49917* / DNA ligase 4*  / reaction






 

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