ENSMUSG00000049717


Mus musculus

Features
Gene ID: ENSMUSG00000049717
  
Biological name :Lig4
  
Synonyms : Lig4 / ligase IV, DNA, ATP-dependent / Q8BTF7
  
Possible biological names infered from orthology : DNA ligase 4 / P49917
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 9969049
Gene end: 9977686
  
Corresponding Affymetrix probe sets: 10576946 (MoGene1.0st)   1439487_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093130
Ensembl peptide - ENSMUSP00000130807
NCBI entrez gene - 319583     See in Manteia.
MGI - MGI:1335098
RefSeq - XM_017312854
RefSeq - NM_176953
RefSeq Peptide - NP_795927
swissprot - Q8BTF7
Ensembl - ENSMUSG00000049717
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lig4ENSDARG00000060620Danio rerio
 LIG4ENSGALG00000016854Gallus gallus
 LIG4ENSG00000174405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR001357  BRCT domain
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR021536  DNA ligase IV domain
 IPR029710  DNA ligase 4
 IPR036420  BRCT domain superfamily
 IPR036599  DNA ligase, ATP-dependent, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair ISO
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0002328 pro-B cell differentiation IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006266 DNA ligation ISO
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling ISO
 biological_processGO:0006302 double-strand break repair ISO
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining ISO
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010165 response to X-ray ISO
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0033151 V(D)J recombination ISO
 biological_processGO:0033152 immunoglobulin V(D)J recombination IMP
 biological_processGO:0033153 T cell receptor V(D)J recombination IMP
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045190 isotype switching IMP
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 biological_processGO:0051102 DNA ligation involved in DNA recombination IMP
 biological_processGO:0051103 DNA ligation involved in DNA repair ISO
 biological_processGO:0051276 chromosome organization IGI
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051402 neuron apoptotic process IGI
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0097680 double-strand break repair via classical nonhomologous end joining ISO
 biological_processGO:2001252 positive regulation of chromosome organization ISO
 cellular_componentGO:0000793 condensed chromosome ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex ISO
 cellular_componentGO:0032807 DNA ligase IV complex ISO
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule ISO
 cellular_componentGO:0070419 nonhomologous end joining complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003909 DNA ligase activity ISO
 molecular_functionGO:0003910 DNA ligase (ATP) activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0016874 ligase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2a+,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Nbntm1Jpt/Nbntm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lig4tm1Fwa/Lig4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1.1Gss/Runx1tm1.1Gss
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic Background: Not Specified

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Nbntm1Jpt/Nbntm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Mre11atm1Jpt/Mre11atm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Pmc/Lig4tm1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1.1Gss/Runx1tm1.1Gss
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Trp53tm1Tyj/Trp53+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Pmc/Lig4tm1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Trp53tm1Tyj/Trp53+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53+,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxa1tm1Khk/Foxa1tm1Khk,Foxa2tm1Khk/Foxa2tm1Khk,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Nbntm1Jpt/Nbntm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lig4tm1Fwa/Lig4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Icrf/Lig4+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Atmtm1Pmc/Atm+,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Cdkn2atm1Rdp/Cdkn2a+,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53+,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Lig4tm1Fwa/Lig4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Xrcc5tm1Dbr/Xrcc5tm1Dbr,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Xrcc5tm1Dbr/Xrcc5+,Lig4tm1Fwa/Lig4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Tg(Cr2-cre)3Cgn/0,Xrcc4tm2Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2a+,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Tg(Cr2-cre)3Cgn/0,Xrcc4tm2Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004228 decreased cellular sensitivity to ionizing radiation "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Mre11atm1Jpt/Mre11atm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: involves: 129

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Apoetm1Bres Esr1tm1Ksk

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Tg(Cr2-cre)3Cgn/0,Xrcc4tm2Fwa/Xrcc4tm2Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ightm2Cgn/Ightm2Cgn,Igktm1Rsky/Igktm1Rsky,Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004941 abnormal regulatory T cell morphology "any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic Background: Not Specified

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53tm1Tyj,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Trp53tm1Tyj/Trp53+,Xrcc2tm2Pmc/Xrcc2tm2Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008754 abnormal T cell receptor V(D)J recombination "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Ptch1tm1Mps/Ptch1+,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Mre11atm1Jpt/Mre11atm1Jpt
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Lig4tm1Pmc/Lig4tm1Pmc,Nbntm1Jpt/Nbntm1Jpt,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Trp53tm1Tyj/Trp53+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2a+,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

Allelic Composition: Lig4tm1Icrf/Lig4tm1Icrf,Nbntm1Jpt/Nbntm1Jpt
Genetic Background: involves: 129 * 129S7/SvEvBrd

Allelic Composition: Paxxem1Spj/Paxxem1Spj,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Xrcc5tm1Dbr/Xrcc5tm1Dbr,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pkd1m1Bei/Pkd1m1Bei
Genetic Background: involves: A/J * FVB/N

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Lig4tiny/Lig4tiny
Genetic Background: C57BL/6-Lig4tiny

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0012504 increased forebrain apoptosis "increase in the number of cells of the forebrain undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0013182 increased spinal cord apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021615 Xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / complex
 ENSMUSG00000020474 Polm / Q9JIW4 / polymerase (DNA directed), mu / Q9NP87* / DNA polymerase mu*  / reaction
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction
 ENSMUSG00000025218 Poll / Q9QXE2 / polymerase (DNA directed), lambda / Q9UGP5* / DNA polymerase lambda*  / reaction
 ENSMUSG00000022471 Xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / reaction
 ENSMUSG00000026187 Xrcc5 / P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction
 ENSMUSG00000022672 Prkdc / P97313 / DNA-dependent protein kinase catalytic subunit / P78527* / protein kinase, DNA-activated, catalytic polypeptide*  / reaction






 

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