ENSMUSG00000022471


Mus musculus

Features
Gene ID: ENSMUSG00000022471
  
Biological name :Xrcc6
  
Synonyms : X-ray repair complementing defective repair in Chinese hamster cells 6 / Xrcc6
  
Possible biological names infered from orthology : P12956 / X-ray repair cross complementing 6
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 81987835
Gene end: 82040085
  
Corresponding Affymetrix probe sets: 10425632 (MoGene1.0st)   1417437_at (Mouse Genome 430 2.0 Array)   1428504_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097968
Ensembl peptide - ENSMUSP00000155606
Ensembl peptide - ENSMUSP00000131212
Ensembl peptide - ENSMUSP00000129628
Ensembl peptide - ENSMUSP00000127927
Ensembl peptide - ENSMUSP00000068559
NCBI entrez gene - 14375     See in Manteia.
MGI - MGI:95606
RefSeq - XM_011245456
RefSeq - XM_006520445
RefSeq - XM_006520442
RefSeq - NM_010247
RefSeq - XM_006520443
RefSeq - XM_006520444
RefSeq Peptide - NP_034377
swissprot - E9Q4A4
swissprot - A0A0R4J187
swissprot - E9PZD4
swissprot - E9Q163
Ensembl - ENSMUSG00000022471
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrcc6ENSDARG00000071551Danio rerio
 XRCC6ENSGALG00000011932Gallus gallus
 XRCC6ENSG00000196419Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR005160  Ku70/Ku80 C-terminal arm
 IPR005161  Ku70/Ku80, N-terminal alpha/beta
 IPR006164  Ku70/Ku80 beta-barrel domain
 IPR006165  Ku70
 IPR016194  SPOC-like, C-terminal domain superfamily
 IPR027388  Ku70, bridge and pillars domain superfamily
 IPR036361  SAP domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0071475 cellular hyperosmotic salinity response IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:0097680 double-strand break repair via classical nonhomologous end joining IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0043564 Ku70:Ku80 complex IEA
 cellular_componentGO:0070419 nonhomologous end joining complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Bmp2tm1Vrs/Bmp2tm1Vrs,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ightm2Cgn/Igh+,Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria4tm1Yfkk/Gria4tm1Yfkk
Genetic Background: B6.129S-Gria4tm1Yfkk

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria4tm1Yfkk/Gria4tm1Yfkk
Genetic Background: B6.129S-Gria4tm1Yfkk

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008213 absent immature B cells "absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020474 Polm / Q9JIW4 / polymerase (DNA directed), mu / Q9NP87* / DNA polymerase mu*  / reaction
 ENSMUSG00000021615 Xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / reaction
 ENSMUSG00000025218 Poll / Q9QXE2 / polymerase (DNA directed), lambda / Q9UGP5* / DNA polymerase lambda*  / reaction
 ENSMUSG00000022672 Prkdc / P97313 / DNA-dependent protein kinase catalytic subunit / P78527* / protein kinase, DNA-activated, catalytic polypeptide*  / complex / reaction
 ENSMUSG00000026187 Xrcc5 / P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / complex / reaction
 ENSMUSG00000022471 Xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / complex
 ENSMUSG00000049717 Lig4 / Q8BTF7 / ligase IV, DNA, ATP-dependent / P49917* / DNA ligase 4*  / reaction






 

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