ENSMUSG00000026187


Mus musculus

Features
Gene ID: ENSMUSG00000026187
  
Biological name :Xrcc5
  
Synonyms : P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5 / Xrcc5
  
Possible biological names infered from orthology : P13010 / X-ray repair cross complementing 5
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 72307421
Gene end: 72394952
  
Corresponding Affymetrix probe sets: 10347232 (MoGene1.0st)   1451968_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027379
NCBI entrez gene - 22596     See in Manteia.
MGI - MGI:104517
RefSeq - XM_017319872
RefSeq - NM_009533
RefSeq - XM_006495892
RefSeq - XM_006495893
RefSeq Peptide - NP_033559
swissprot - P27641
Ensembl - ENSMUSG00000026187
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrcc5ENSDARG00000099298Danio rerio
 XRCC5ENSGALG00000011492Gallus gallus
 XRCC5ENSG00000079246Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005160  Ku70/Ku80 C-terminal arm
 IPR005161  Ku70/Ku80, N-terminal alpha/beta
 IPR006164  Ku70/Ku80 beta-barrel domain
 IPR014893  Ku, C-terminal
 IPR016194  SPOC-like, C-terminal domain superfamily
 IPR024193  Ku80
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR036494  Ku, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IBA
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining ISO
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071475 cellular hyperosmotic salinity response IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:1904430 negative regulation of t-circle formation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0043564 Ku70:Ku80 complex ISO
 cellular_componentGO:0070419 nonhomologous end joining complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016817 hydrolase activity, acting on acid anhydrides IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042162 telomeric DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lig4tm1Fwa/Lig4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lig4tm1Fwa/Lig4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Xrcc5tm1Dbr/Xrcc5tm1Dbr,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Xrcc5tm1Dbr/Xrcc5+,Lig4tm1Fwa/Lig4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Xrcc5tm1Dbr/Xrcc5+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

 MP:0008925 increased granule neuron number "greater number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Paxxem1Spj/Paxxem1Spj,Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Xrcc5tm1Dbr/Xrcc5tm1Dbr,Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: KitlSl-21J/Kitl+
Genetic Background: B10.BR H2k H2-T18a/SgSnJ-KitlSl-21J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020474 Polm / Q9JIW4 / polymerase (DNA directed), mu / Q9NP87* / DNA polymerase mu*  / reaction
 ENSMUSG00000021615 Xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / reaction
 ENSMUSG00000025218 Poll / Q9QXE2 / polymerase (DNA directed), lambda / Q9UGP5* / DNA polymerase lambda*  / reaction
 ENSMUSG00000022672 Prkdc / P97313 / DNA-dependent protein kinase catalytic subunit / P78527* / protein kinase, DNA-activated, catalytic polypeptide*  / complex / reaction
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / complex / reaction
 ENSMUSG00000026187 Xrcc5 / P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / complex
 ENSMUSG00000022471 Xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / complex
 ENSMUSG00000049717 Lig4 / Q8BTF7 / ligase IV, DNA, ATP-dependent / P49917* / DNA ligase 4*  / reaction






 

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