ENSMUSG00000026648


Mus musculus

Features
Gene ID: ENSMUSG00000026648
  
Biological name :Dclre1c
  
Synonyms : Dclre1c / Protein artemis / Q8K4J0
  
Possible biological names infered from orthology : DNA cross-link repair 1C / Q96SD1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A1
Gene start: 3424131
Gene end: 3464130
  
Corresponding Affymetrix probe sets: 10468949 (MoGene1.0st)   1457679_at (Mouse Genome 430 2.0 Array)   1458361_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100053
Ensembl peptide - ENSMUSP00000054300
Ensembl peptide - ENSMUSP00000098031
Ensembl peptide - ENSMUSP00000110718
Ensembl peptide - ENSMUSP00000116883
NCBI entrez gene - 227525     See in Manteia.
MGI - MGI:2441769
RefSeq - XM_017317177
RefSeq - NM_001110214
RefSeq - NM_001302674
RefSeq - NM_001302684
RefSeq - NM_146114
RefSeq - NM_175683
RefSeq - XM_006497457
RefSeq - XM_006497458
RefSeq - XM_006497459
RefSeq - XM_006497460
RefSeq - XM_006497461
RefSeq - XM_006497462
RefSeq - XM_011238971
RefSeq - XM_011238972
RefSeq - XM_006497452
RefSeq - XM_006497453
RefSeq - XM_006497454
RefSeq - XM_006497455
RefSeq - XM_006497456
RefSeq Peptide - NP_001103684
RefSeq Peptide - NP_001289603
RefSeq Peptide - NP_001289613
RefSeq Peptide - NP_666226
RefSeq Peptide - NP_783614
swissprot - Q32MX8
swissprot - Q8K4J0
swissprot - F7BA65
Ensembl - ENSMUSG00000026648
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5RGE5ENSDARG00000045704Danio rerio
 DCLRE1CENSGALG00000013926Gallus gallus
 Q96SD1ENSG00000152457Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C7W7 / Dclre1b / 5 exonuclease Apollo / Q9H816* / DNA cross-link repair 1B*ENSMUSG0000002784518
Dclre1a / DNA cross-link repair 1A / Q6PJP8*ENSMUSG0000002507712


Protein motifs (from Interpro)
Interpro ID Name
 IPR001279  Metallo-beta-lactamase
 IPR011084  DNA repair metallo-beta-lactamase
 IPR036866  Ribonuclease Z/Hydroxyacylglutathione hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IBA
 biological_processGO:0006310 DNA recombination IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0031848 protection from non-homologous end joining at telomere IBA
 biological_processGO:0033151 V(D)J recombination IMP
 biological_processGO:0036297 interstrand cross-link repair IBA
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IBA
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0070419 nonhomologous end joining complex IEA
 molecular_functionGO:0000014 single-stranded DNA endodeoxyribonuclease activity IEA
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008409 5"-3" exonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035312 5"-3" exodeoxyribonuclease activity IBA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Sun1tm1Mhan/Sun1tm1Mhan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: March7Gt(ROSABetageo)1Summ/March7+
Genetic Background: involves: BALB/c

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Men1tm1Ctre/Men1+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C3H * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Sun1tm1Mhan/Sun1tm1Mhan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Men1tm1Ctre/Men1+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr2tm2Amks/Ryr2+
Genetic Background: B6.129-Ryr2tm2Amks

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: March7Gt(ROSABetageo)1Summ/March7+
Genetic Background: involves: BALB/c

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: March7Gt(ROSABetageo)1Summ/March7+
Genetic Background: involves: BALB/c

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: March7Gt(ROSABetageo)1Summ/March7+
Genetic Background: involves: BALB/c

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dclre1cm1Btlr/Dclre1cm1Btlr
Genetic Background: C57BL/6J-Dclre1cm1Btlr

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dclre1cm1Btlr/Dclre1cm1Btlr
Genetic Background: C57BL/6J-Dclre1cm1Btlr

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Dclre1cm1Btlr/Dclre1cm1Btlr
Genetic Background: C57BL/6J-Dclre1cm1Btlr

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Dclre1cm1Btlr/Dclre1cm1Btlr
Genetic Background: C57BL/6J-Dclre1cm1Btlr

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oprd1tm1.2Cgrf/Oprd1tm1.2Cgrf
Genetic Background: involves: 129 * C57BL/6J

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1cm1Btlr/Dclre1cm1Btlr
Genetic Background: C57BL/6J-Dclre1cm1Btlr

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0008213 absent immature B cells "absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0008247 abnormal mononuclear leukocyte morphology "any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
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Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008754 abnormal T cell receptor V(D)J recombination "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dclre1ctm1Fwa/Dclre1ctm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm1Jsek/Dclre1ctm1Jsek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm2.2Jpdv/Dclre1ctm2.2Jpdv
Genetic Background: B6.129S2-Dclre1ctm2.2Jpdv

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
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Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

 MP:0010250 absent thymus cortex "lacking the outer part of the thymus lobule which surrounds the medulla and is normally composed of closely packed lymphocytes" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm2Mcow/Dclre1ctm2Mcow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Dclre1cm1Btlr/Dclre1cm1Btlr
Genetic Background: C57BL/6J-Dclre1cm1Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Dclre1cm1Btlr/Dclre1cm1Btlr
Genetic Background: C57BL/6J-Dclre1cm1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020474 Polm / Q9JIW4 / polymerase (DNA directed), mu / Q9NP87* / DNA polymerase mu*  / reaction
 ENSMUSG00000022672 Prkdc / P97313 / DNA-dependent protein kinase catalytic subunit / P78527* / protein kinase, DNA-activated, catalytic polypeptide*  / complex / reaction
 ENSMUSG00000021615 Xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / reaction
 ENSMUSG00000025218 Poll / Q9QXE2 / polymerase (DNA directed), lambda / Q9UGP5* / DNA polymerase lambda*  / reaction
 ENSMUSG00000026187 Xrcc5 / P27641 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / complex / reaction
 ENSMUSG00000022471 Xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction / complex
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / reaction / complex
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction / complex
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction / complex
 ENSMUSG00000049717 Lig4 / Q8BTF7 / ligase IV, DNA, ATP-dependent / P49917* / DNA ligase 4*  / reaction






 

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