ENSMUSG00000025077


Mus musculus

Features
Gene ID: ENSMUSG00000025077
  
Biological name :Dclre1a
  
Synonyms : Dclre1a / DNA cross-link repair 1A
  
Possible biological names infered from orthology : Q6PJP8
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: D2
Gene start: 56529167
Gene end: 56548222
  
Corresponding Affymetrix probe sets: 10468639 (MoGene1.0st)   1417904_at (Mouse Genome 430 2.0 Array)   1432097_a_at (Mouse Genome 430 2.0 Array)   1442329_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138290
Ensembl peptide - ENSMUSP00000138364
Ensembl peptide - ENSMUSP00000138537
NCBI entrez gene - 55947     See in Manteia.
MGI - MGI:1930042
RefSeq - XM_011247297
RefSeq - NM_018831
RefSeq - XM_006527216
RefSeq - XM_006527217
RefSeq - XM_006527218
RefSeq Peptide - NP_061301
swissprot - S4R1N2
swissprot - S4R1T3
swissprot - S4R284
Ensembl - ENSMUSG00000025077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dclre1aENSDARG00000091768Danio rerio
 DCLRE1AENSGALG00000008938Gallus gallus
 Q6PJP8ENSG00000198924Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*ENSMUSG000000266488
Q8C7W7 / Dclre1b / 5 exonuclease Apollo / Q9H816* / DNA cross-link repair 1B*ENSMUSG000000278455


Protein motifs (from Interpro)
Interpro ID Name
 IPR011084  DNA repair metallo-beta-lactamase
 IPR036866  Ribonuclease Z/Hydroxyacylglutathione hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0035312 5"-3" exodeoxyribonuclease activity IEA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts13s/Adamts13s
Genetic Background: 129.B6-Adamts13s

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Adamts13s/Adamts13s
Genetic Background: 129.B6-Adamts13s

Allelic Composition: Dclre1atm1Rleg/Dclre1a+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dclre1atm1Rleg/Dclre1atm1Rleg,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Adamts13s/Adamts13s
Genetic Background: 129.B6-Adamts13s

Allelic Composition: Dclre1atm1Rleg/Dclre1a+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Adamts13s/Adamts13s
Genetic Background: 129.B6-Adamts13s

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adamts13s/Adamts13s
Genetic Background: 129.B6-Adamts13s

Allelic Composition: Dclre1atm1Rleg/Dclre1a+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dclre1atm1Rleg/Dclre1atm1Rleg,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts13s/Adamts13s
Genetic Background: 129.B6-Adamts13s

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Adamts13s/Adamts13s
Genetic Background: 129.B6-Adamts13s

Allelic Composition: Dclre1atm1Rleg/Dclre1a+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009442 ovarian teratoma "a usually benign tumor found in the ovary that is the result of an anomaly of oogenesis and typically contains a diversity of tissues often representing all organ systems e.g. hair, teeth, bone, thyroid, nerve tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts13s/Adamts13s
Genetic Background: 129.B6-Adamts13s

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Dclre1atm1Rleg/Dclre1atm1Rleg
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclre1atm1Rleg/Dclre1atm1Rleg
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dclre1atm1Rleg/Dclre1a+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Dclre1atm1Rleg/Dclre1atm1Rleg
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Dclre1atm1Rleg/Dclre1atm1Rleg
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dclre1atm1Rleg/Dclre1a+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dclre1atm1Rleg/Dclre1atm1Rleg,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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